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Current Pharmacogenomics and Personalized Medicine

Editor-in-Chief

ISSN (Print): 1875-6921
ISSN (Online): 1875-6913

Review Article

Perspectives for the Comet Assay in Assessing Genotoxicity - A Review

Author(s): Siti S. Zulkifli, Norhayati Luddin and Kannan P. Thirumulu

Volume 14, Issue 1, 2016

Page: [29 - 35] Pages: 7

DOI: 10.2174/1875692115666161227154706

Price: $65

Abstract

The employment of comet assay has gained wide importance in various areas that focus on human bio-monitoring, genetic toxicology, molecular epidemiology and ecogenotoxicity. Comet assay has become among the standard methods for evaluating genotoxicity by the determination of DNA damage caused by mutagens, and this assay has been extensively applied by the researchers for the past 20 years. This review discusses comet assay, as well as its application in various fields.

Keywords: Bio-monitoring, comet assay, DNA damage, genotoxicity, mutagens, toxicology.

Graphical Abstract


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