Abstract
Nonsteroidal anti-inflammatory drugs (NSAIDs) are among the most widely used drugs worldwide and represent a mainstay in the therapy of acute and chronic pain and inflammation. The traditional NSAIDs like ibuprofen (I) contain free carboxylic acid group which can produce gastrointestinal (GI) damage for long-term use.
Objective: In order to obtain the novel NSAIDs with less side effects; carboxylic acid moiety has been modified into various amide groups which is the most active area of research in this family. Method: In this research, synthesis of various pharmacological heterocyclic amides of ibuprofen is described. All the new compounds were tested for their analgesic and anti-inflammatory activities in mice and compared with standard (Ibuprofen) and control (saline) groups. Results & Conclusion: The results revealed that all the synthesized compounds (III-VI) exhibited more analgesic and anti-inflammatory activities in tail immersion (as a model of acute thermal pain), formalin (as a model of acute chemical and chronic pain) and paw edema (as a model of acute inflammation) tests when compared with standard and control animals. These pharmacological activities were significant for VI compared to other new compounds (III-V) which may be concern to more effective role of morpholin for the reduction of pain and inflammation compared to other used heterocyclic amines.Keywords: Analgesic, anti-inflammatory, ibuprofen, NSAIDs, pharmacological heterocyclic amides.
Graphical Abstract
Mini-Reviews in Medicinal Chemistry
Title:Synthesis and Study of Analgesic and Anti-inflammatory Activities of Amide Derivatives of Ibuprofen
Volume: 17 Issue: 9
Author(s): Abbas Ahmadi*, Mohsen Khalili, Zahra Olama, Shirin Karami and Babak Nahri-Niknafs
Affiliation:
- Department of Medicinal Chemistry, Faculty of Science, Islamic Azad University, P.O. Box: 31485- 313, Karaj,Iran
Keywords: Analgesic, anti-inflammatory, ibuprofen, NSAIDs, pharmacological heterocyclic amides.
Abstract: Nonsteroidal anti-inflammatory drugs (NSAIDs) are among the most widely used drugs worldwide and represent a mainstay in the therapy of acute and chronic pain and inflammation. The traditional NSAIDs like ibuprofen (I) contain free carboxylic acid group which can produce gastrointestinal (GI) damage for long-term use.
Objective: In order to obtain the novel NSAIDs with less side effects; carboxylic acid moiety has been modified into various amide groups which is the most active area of research in this family. Method: In this research, synthesis of various pharmacological heterocyclic amides of ibuprofen is described. All the new compounds were tested for their analgesic and anti-inflammatory activities in mice and compared with standard (Ibuprofen) and control (saline) groups. Results & Conclusion: The results revealed that all the synthesized compounds (III-VI) exhibited more analgesic and anti-inflammatory activities in tail immersion (as a model of acute thermal pain), formalin (as a model of acute chemical and chronic pain) and paw edema (as a model of acute inflammation) tests when compared with standard and control animals. These pharmacological activities were significant for VI compared to other new compounds (III-V) which may be concern to more effective role of morpholin for the reduction of pain and inflammation compared to other used heterocyclic amines.Export Options
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Cite this article as:
Ahmadi Abbas*, Khalili Mohsen, Olama Zahra, Karami Shirin and Nahri-Niknafs Babak, Synthesis and Study of Analgesic and Anti-inflammatory Activities of Amide Derivatives of Ibuprofen, Mini-Reviews in Medicinal Chemistry 2017; 17 (9) . https://dx.doi.org/10.2174/1389557516666161226155951
DOI https://dx.doi.org/10.2174/1389557516666161226155951 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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