摘要
CREB是一种调节不同细胞反应普遍存在的转录因子。其对S133的磷酸化是其在神经和视觉系统上激活比较重要的一步。激活的CREB在神经系统的发展、保护、学习、记忆和可塑性的调节有关。此外,SUMO化修饰,作为蛋白重要的后修饰优化在维持大鼠海马CREB活化以增强长期记忆等方面起着关键的作用。在视觉系统中,虽然在S133磷酸化CREB的激活与神经系统上的像素,CREB SUMO化修饰的作用仍需要进行探索。本文探索了CREB的功能及其在两个系统的磷酸化和SUMU化。
关键词: CREB,眼睛,镜,磷酸化,SUMO化修饰,神经系统,视觉系统
Current Molecular Medicine
Title:Regulation of CREB Functions by Phosphorylation and Sumoylation in Nervous and Visual Systems
Volume: 16 Issue: 10
关键词: CREB,眼睛,镜,磷酸化,SUMO化修饰,神经系统,视觉系统
摘要: CREB is an ubiquitous transcription factor regulating diverse cellular responses. Its phosphorylation at S133 is an essential event for its activation in both nervous and visual systems. The activated CREB is implicated in the regulation of development, protection, learning, memory and plasticity in the nerve system. Moreover, sumoylation, an important post-translational modification of protein, plays a key role in sustaining CREB activation in the rat hippocampus in order to enhance the long-term memory and other aspects. In the visual system, although the CREB activation by phosphorylation at S133 is similar to that as observed in the nervous system, the role of CREB sumoylation remains to be explored. This review will discuss the aspects of CREB functions and their regulation by phosphorylation and sumoylation in both systems.
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Regulation of CREB Functions by Phosphorylation and Sumoylation in Nervous and Visual Systems, Current Molecular Medicine 2016; 16 (10) . https://dx.doi.org/10.2174/1566524016666161223110106
DOI https://dx.doi.org/10.2174/1566524016666161223110106 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
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