摘要
CREB是一种调节不同细胞反应普遍存在的转录因子。其对S133的磷酸化是其在神经和视觉系统上激活比较重要的一步。激活的CREB在神经系统的发展、保护、学习、记忆和可塑性的调节有关。此外,SUMO化修饰,作为蛋白重要的后修饰优化在维持大鼠海马CREB活化以增强长期记忆等方面起着关键的作用。在视觉系统中,虽然在S133磷酸化CREB的激活与神经系统上的像素,CREB SUMO化修饰的作用仍需要进行探索。本文探索了CREB的功能及其在两个系统的磷酸化和SUMU化。
关键词: CREB,眼睛,镜,磷酸化,SUMO化修饰,神经系统,视觉系统
Current Molecular Medicine
Title:Regulation of CREB Functions by Phosphorylation and Sumoylation in Nervous and Visual Systems
Volume: 16 Issue: 10
关键词: CREB,眼睛,镜,磷酸化,SUMO化修饰,神经系统,视觉系统
摘要: CREB is an ubiquitous transcription factor regulating diverse cellular responses. Its phosphorylation at S133 is an essential event for its activation in both nervous and visual systems. The activated CREB is implicated in the regulation of development, protection, learning, memory and plasticity in the nerve system. Moreover, sumoylation, an important post-translational modification of protein, plays a key role in sustaining CREB activation in the rat hippocampus in order to enhance the long-term memory and other aspects. In the visual system, although the CREB activation by phosphorylation at S133 is similar to that as observed in the nervous system, the role of CREB sumoylation remains to be explored. This review will discuss the aspects of CREB functions and their regulation by phosphorylation and sumoylation in both systems.
Export Options
About this article
Cite this article as:
Regulation of CREB Functions by Phosphorylation and Sumoylation in Nervous and Visual Systems, Current Molecular Medicine 2016; 16 (10) . https://dx.doi.org/10.2174/1566524016666161223110106
DOI https://dx.doi.org/10.2174/1566524016666161223110106 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Telomere Maintenance Mechanisms in Cancer: Clinical Implications
Current Pharmaceutical Design A Review of the Current Role of Proton Therapy in Modern Oncology
Current Drug Therapy Placebo Effect in Obsessive-Compulsive Disorder (OCD). Placebo Response and Placebo Responders in OCD: The Trend Over Time
Current Neuropharmacology The Changing Face of HDAC Inhibitor Depsipeptide
Current Cancer Drug Targets From Cocaine to Ropivacaine: The History of Local Anesthetic Drugs
Current Topics in Medicinal Chemistry The Evolution of Schizophrenia: A Model for Selection by Infection, with a Focus on NAD
Current Pharmaceutical Design Treatment of Insulin Resistance in the Neurodegeneration
Recent Patents on CNS Drug Discovery (Discontinued) Congenital Choledochal Malformation – Current Concepts and Classification
Current Pediatric Reviews HIV Genetic Diversity: Biological and Public Health Consequences
Current HIV Research Ghrelin: A Gastric Peptide that Regulates Hypothalamic Control of Feeding
Current Medicinal Chemistry - Central Nervous System Agents Epigenetic Regulation of Cytochrome P450 Enzymes and Clinical Implication
Current Drug Metabolism Role of Immunostimulatory Molecules in Poultry Vaccines
Recent Patents on Biotechnology Protein Extracts from Somaclonal Mistletoe (Viscum Album L.) Callus with Increased Tumor Cytotoxic Activity in Vitro
Current Bioactive Compounds Mechanisms of Control of Neuron Survival by the Endocannabinoid System
Current Pharmaceutical Design New Treatments for Emerging Cystic Fibrosis Pathogens other than Pseudomonas
Current Pharmaceutical Design Anti-Angiogenic Therapies for Children with Cancer
Current Cancer Drug Targets RANKL/RANK/OPG: Key Therapeutic Target in Bone Oncology
Current Drug Discovery Technologies Mitochondrial Dysfunction in Gliomas: Pharmacotherapeutic Potential of Natural Compounds
Current Neuropharmacology Berberine Nanoencapsulation Attenuates Hallmarks of Scoplomine Induced Alzheimer's-Like Disease in Rats
Current Reviews in Clinical and Experimental Pharmacology Congenital Disorders of Glycosylation (CDG): Update and Perspectives
Current Pediatric Reviews