摘要
背景:治疗剂在大脑中的成功传递是非常具有挑战性的,这使得治疗各种脑疾病非常困难。 造成这种困难的主要原因之一是在脑中存在生理屏障,如血脑屏障(BBB)和血液脑脊液(CSF)屏障。 这些障碍非常具体,限制了水溶性物质和电离分子的进入。 目的:本文着重于经颅路径,经颅超声(FUS)以及经颅超声(FUS)交付技术和本系统近期更新。 结果:本研究描述了FUS结合各种其他技术非常有效地开启了BBB。 结论:使用各种FUS技术治疗药物的治疗开辟了治疗CNS疾病的新视角。
关键词: 血脑屏障,经颅输送,聚焦超声,微泡,药物递送。
图形摘要
Current Drug Targets
Title:Recent Advances in Transcranial Focused Ultrasound (FUS) Triggered Brain Delivery
Volume: 18 Issue: 11
关键词: 血脑屏障,经颅输送,聚焦超声,微泡,药物递送。
摘要: Background: Successful delivery of therapeutic agents in the brain is very challenging, which makes treatment of various brain disorders very difficult. One of the major causes of this difficulty is the presence of physiological barriers in the brain like blood brain barrier (BBB) and blood cerebrospinal fluid (CSF) barrier. These barriers are very specific and restrict the entry of water soluble agents and ionized molecule.
Objective: The current article focuses on the transcranial route, transcranial focused ultrasound (FUS), and the techniques involved in transcranial focused ultrasound (FUS) delivery and recent updates of this system. Results: The study describes that the FUS in conjunction with various other techniques opens the BBB very effectively. Conclusion: The administration of therapeutic agent using various FUS techniques opens a new perspective in treating CNS diseases.Export Options
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Cite this article as:
Recent Advances in Transcranial Focused Ultrasound (FUS) Triggered Brain Delivery, Current Drug Targets 2017; 18 (11) . https://dx.doi.org/10.2174/1389450117666161222160025
DOI https://dx.doi.org/10.2174/1389450117666161222160025 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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