Endothelial Progenitor Cells as a Therapeutic Approach for Intracerebral Hemorrhage

Title:Endothelial Progenitor Cells as a Therapeutic Approach for Intracerebral Hemorrhage

Volume: 23 Issue: 15

Author(s): Juan Pías-Peleteiro, Francisco Campos, María Perez-Mato, Esteban Lopez-Arias, Manuel Rodriguez-Yanez, Jose Castillo*Tomas Sobrino*

Affiliation:

• Clinical Neurosciences Research Laboratory, Department of Neurology, Hospital Clínico Universitario, Health Research Institute of Santiago de Compostela (IDIS), Universidade de Santiago de Compostela, Santiago de Compostela,Spain

• Department of Neurology, Clinical Neurosciences Research Laboratory, Hospital Clínico Universitário, Travesa da Choupana S/N, 15706 - Santiago de Compostela,Spain

Keywords: Angiogenesis, cellular therapy, endothelial progenitor cells, intracerebral hemorrhage, outcome, vasculogenesis.

Abstract: Background: Intracerebral hemorrhage (ICH) is the most lethal subtype of stroke, a leading cause of death and disability in developed countries. Therapeutic options are notably limited. There is no specific pharmacological treatment, and early surgery has few indications that represent only a small clinically relevant survival advantage. It is therefore mandatory to investigate repairing processes after ICH in order to develop related therapeutic strategies.

Methods: The goal of this review is to discuss the current status of knowledge about the potential therapeutic role of endothelial progenitor cells (EPCs) in ICH, as well as the possible molecular mechanisms and future perspectives.

Results: ICH is characterized by a primary vascular rupture, followed by a secondary vascular tearing due to the peripheral pressure exerted by the hematoma. Hypoperfusion may also play a role, although not as markedly as in ischemic stroke. In this context, the repairing of damaged vessels and the development of new ones seem logical therapeutic targets. Circulating EPCs have been suggested to play a major role in re-endothelization, angiogenesis and vasculogenesis. Congruently, EPC levels have been associated with good neurological and functional outcome as well as with reduced residual volume in patients with acute ICH.

Conclusion: An EPC-based therapy, acting primarily through angiogenic mechanisms, may be a valid therapeutic option in ICH.

Cite this article as:

Pías-Peleteiro Juan, Campos Francisco, Perez-Mato María, Lopez-Arias Esteban, Rodriguez-Yanez Manuel, Castillo Jose*, Sobrino Tomas*, Endothelial Progenitor Cells as a Therapeutic Approach for Intracerebral Hemorrhage, Current Pharmaceutical Design 2017; 23 (15) . https://dx.doi.org/10.2174/1381612822666161221153937

DOI https://dx.doi.org/10.2174/1381612822666161221153937	Print ISSN 1381-6128
Publisher Name Bentham Science Publisher	Online ISSN 1873-4286