将Legumain定位为癌症中的新型治疗策略

Title:Targeting Legumain As a Novel Therapeutic Strategy in Cancers

Volume: 18 Issue: 11

关键词: Legumain，癌症，肿瘤微环境，疫苗，偶氮肽，小分子，前药。

摘要: Background: Recent reports indicate that the tumor microenvironment plays a pivotal role in cancer development and progression, leading to a paradigm shift in the way cancer is studied and targeted. In contrast to traditional approaches, where only tumor cells are targeted for the treatment, an emerging approach is to develop therapeutics which target the tumor microenvironment while complementing or enhancing current treatments. Legumain (LGMN) is a newly identified target which is highly expressed in the tumor microenvironment and in tumor cells, and holds potential both as a biomarker and as a therapeutic target.

Cite this article as:

Targeting Legumain As a Novel Therapeutic Strategy in Cancers, Current Drug Targets 2017; 18 (11) . https://dx.doi.org/10.2174/1389450117666161216125344