摘要
早泄(PE)是最常见的男性性功能障碍之一。它的特征是在阴道渗透之前或不久之后发生的射精,这对个体和他的伴侣造成显着的心理困扰。 PE的确切原因仍然未知,但提出了几种机制,这些机制涉及神经生理学,社会心理学和认知因素的复杂相互作用。我们讨论血清素,一氧化氮,磷酸二酯酶和其他神经递质的作用。 PE的治疗倾向于与其他性困难,特别是勃起功能障碍(ED)共同发生。选择性5-羟色胺再摄取抑制剂(SSRIs)和达波西汀的治疗也详细讨论。治疗策略需要一种全面的整体方法,包括精神药理学药物和认知行为疗法(CBT)的组合。本综述强调了下丘脑 - 神经和回声情感电路的整合,并讨论了PE患者的病因和治疗。
关键词: 认知行为疗法,dopexetine,病理生理学,早泄,SSRIs,勃起功能障碍。
图形摘要
Current Drug Targets
Title:Understanding the Pathophysiology of Premature Ejaculation: Bridging the Link between Pharmacological and Psychological Interventions
Volume: 19 Issue: 8
关键词: 认知行为疗法,dopexetine,病理生理学,早泄,SSRIs,勃起功能障碍。
摘要: Premature ejaculation (PE) is one of the commonest male sexual dysfunctions. It is characterized by ejaculation which occurs before or soon after vaginal penetration, which causes significant psychological distress to the individual, and his partner. The exact cause of PE is still unknown but several mechanisms are proposed, and these involve complex interactions of neurophysiological, psychosocial, and cognitive factors. We discuss the role of serotonin, nitric oxide, phosphodiesterase enzymes and other neurotransmitters. Treatment of PE tends to co-occur with other sexual difficulties, especially erectile dysfunction (ED). Treatment with selective serotonin reuptake inhibitors (SSRIs) and Dapoxitene are also discussed in detail. The treatment strategy requires a comprehensive holistic approach incorporating both combination of psychopharmacological agent and cognitive-behavioral therapy (CBT). The present review highlights the integration of the hypothalamic-neural and reverberating emotional circuit and discusses the etiology and treatment for patients with PE.
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Cite this article as:
Understanding the Pathophysiology of Premature Ejaculation: Bridging the Link between Pharmacological and Psychological Interventions, Current Drug Targets 2018; 19 (8) . https://dx.doi.org/10.2174/1389450117666161215161108
DOI https://dx.doi.org/10.2174/1389450117666161215161108 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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