Biological Drugs in Guillain-Barré Syndrome: An Update

Title:Biological Drugs in Guillain-Barré Syndrome: An Update

Volume: 15 Issue: 7

Author(s): Nazgol Motamed-Gorji*, Nassim Matin, Omidreza Tabatabaie, Piero Pavone, Catia Romano, Raffaele Falsaperla and Giovanna Vitaliti

Affiliation:

• School of Medicine, Tehran University of Medical Sciences, Tehran,Iran

Keywords: Guillain-barré syndrome, immunotherapy, biological, drug, therapy, treatment, monoclonal antibody.

Abstract: Background: Guillain-Barré Syndrome (GBS) is currently considered the most common global cause of acute flaccid paralysis. Currently, standard therapy for Guillain-Barré Syndrome includes intravenous immunoglobulin or plasma exchange. Despite medical advances regarding these treatments, many treated patients do not reach full recovery. Therefore several biological agents have attracted the attentions from researchers during the last decades, and various studies have investigated their role in Guillain-Barré Syndrome.

Objective: The present study aims to address emerging biological approaches to GBS while considering their efficiency and safety in treating the disease.

Materials and Methods: An extensive electronic literature search was conducted by two researchers from April 2016 to July 2016. Original articles, clinical trials, systematic reviews (with or without meta-analysis) and case reports were selected. Titles and abstracts of papers were screened by reviewers to determine whether they met the eligibility criteria, and full texts of the selected articles were retrieved.

Results: Herein authors focused on the literature data concerning emerging biological therapeutic agents, namely anti-C5 monoclonal antibody (Eculizumab), anti-C1q monoclonal antibody, anti-T cell monoclonal antibody, anti-CD2 monoclonal antibody, anti L-selectin monoclonal antibody, anti- CD20 monoclonal antibody (Rituximab), anti-CD52 monoclonal antibody (Alemtuzumab) and cytokine targets. By far, none of these agents have been approved for the treatment of GBS by FDA.

Conclusion: Literature findings represented in current review herald promising results for using these biological targets. Current review represents a summary of what is already in regards and what progress is required to improve the immunotherapeutic approach of treating GBS via future studies.

Cite this article as:

Motamed-Gorji Nazgol*, Matin Nassim, Tabatabaie Omidreza, Pavone Piero, Romano Catia, Falsaperla Raffaele and Vitaliti Giovanna, Biological Drugs in Guillain-Barré Syndrome: An Update, Current Neuropharmacology 2017; 15 (7) . https://dx.doi.org/10.2174/1570159X14666161213114904

DOI https://dx.doi.org/10.2174/1570159X14666161213114904	Print ISSN 1570-159X
Publisher Name Bentham Science Publisher	Online ISSN 1875-6190