摘要
背景:在默认模式网络(DMN)的障碍功能性连接异常可能参与阿尔兹海默病(AD)的进程。后扣带回皮质(PCC)可能是监测AD进程中的影像标志物。 目的:调查患有PCC、AD病人整个大脑、轻度意识障碍(MCI)病人和健康对照组的定向功能连接变化。 方法:共计116名参与者被分成3组:AD (n=32), MCI (n=26), and controls (n=58)。使用静息态功能磁共振成像(rs-fMRI),通过格兰杰因果分析研究定向功能连接。 结果:几乎所有的带有显著差异的定向功能连接都是单向的。与NC组比较,从整个大脑到PCC主要的DMN外部区域中,AD组显示出增强的定向连接,从PCC到整个大脑的主要的DMN外部区域中,AD组显示出减少的定向连接。与NC组相比,从PCC到整个大脑对于双侧楔前叶和中央后回,MCI组显示出增强的定向连接,同时从整个大脑到DMN外部区域PCC,MCI组显示出减少的连接。与MCI组相比,在AD组中异常的定向连接是先支配左半球,可能暗示不对称特性。 结论:在AD患者中,在DMN中的PCC显示出接收和传导信息的无序性,同时这种异常是定向的。
关键词: 轻度意识障碍,阿尔兹海默病,静息态功能大脑成像,定向功能连接,默认模式网络,后扣带回皮质。
Current Alzheimer Research
Title:Directed Functional Connectivity of Posterior Cingulate Cortex and Whole Brain in Alzheimer's Disease and Mild Cognitive Impairment
Volume: 14 Issue: 6
关键词: 轻度意识障碍,阿尔兹海默病,静息态功能大脑成像,定向功能连接,默认模式网络,后扣带回皮质。
摘要: Background: Impaired functional connectivity in the default mode network (DMN) is supposedly involved in Alzheimer’s disease (AD) progression. The posterior cingulate cortex (PCC) might be an imaging marker for monitoring AD progression.
Objective: To investigate the alterations in the directed functional connectivity between the PCC and whole brain in patients with AD, patients with mild cognitive impairment (MCI), and healthy controls. Methods: A total of 116 enrolled participants were divided into three groups: AD (n=32), MCI (n=26), and controls (n=58). Using resting-state functional magnetic resonance imaging (rs-fMRI), the directed functional connectivity was studied using Granger causality analysis (GCA). Results: Almost all of the directed functional connections with significant differences were unidirectional. Compared with the NC group, the AD group showed enhanced directed connectivity from the whole brain to the PCC mainly for regions outside the DMN, and reduced connectivity from the PCC to the whole brain mainly for regions inside the DMN. Compared with the NC group, the MCI group showed enhanced directed connectivity from the PCC to the whole brain for the bilateral precuneus and postcentralgyrus, and reduced connectivity from the whole brain to the PCC for regions outside the DMN. Compared with the MCI group, the abnormal directed connectivity in the AD group was predominantly in the left hemisphere, possibly suggesting asymmetric characteristics. Conclusion: In patients with AD, the PCC in the DMN shows disorders in receiving and transmitting information, and these abnormalities are directional.Export Options
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Cite this article as:
Directed Functional Connectivity of Posterior Cingulate Cortex and Whole Brain in Alzheimer's Disease and Mild Cognitive Impairment, Current Alzheimer Research 2017; 14 (6) . https://dx.doi.org/10.2174/1567205013666161201201000
DOI https://dx.doi.org/10.2174/1567205013666161201201000 |
Print ISSN 1567-2050 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5828 |
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Neuroinflammation is an invariable hallmark of chronic and acute neurodegenerative disorders and has long been considered a potential drug target for Alzheimer?s disease (AD) and dementia. Significant evidence of inflammatory processes as a feature of AD is provided by the presence of inflammatory markers in plasma, CSF and postmortem brain ...read more
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