(RS） - 萘普生对映异构体拆分和（S） - 萘普生在液相色谱法直接和间接对映外消旋化合物中的应用

Title:Enantiomeric Resolution of (RS)-Naproxen and Application of (S)- Naproxen in the Direct and Indirect Enantioseparation of Racemic Compounds by Liquid Chromatography: A Review

Volume: 24 Issue: 8

关键词: （S） - 萘普生，液相色谱，手性衍生试剂，手性固定相，对映体分离，外消旋药物。

摘要: (S)-Naproxen (Npx), an α-aryl propionic acid derivative, belongs to the class of Non-Steroidal Anti-Inflammatory Drugs and is easily available in pure (S)-form. (S)-Npx has been used as a chiral selector for chromatographic separation of a variety of racemates, using both direct and indirect methods, and has been found to be useful and successful as a basic chiral moiety. This review article describes methods for enantioseparation of (RS)-Npx, development of chiral stationary phases based on (S)-Npx and preparation of novel chiral derivatizing reagents synthesized from (S)-Npx along with their application for enantioseparation of several pharmaceutically important racemates.

Cite this article as:

Enantiomeric Resolution of (RS)-Naproxen and Application of (S)- Naproxen in the Direct and Indirect Enantioseparation of Racemic Compounds by Liquid Chromatography: A Review, Current Medicinal Chemistry 2017; 24 (8) . https://dx.doi.org/10.2174/0929867323666161129093052