A Facile Synthesis and Drug Design of Some New Heterocyclic Compounds Incorporating Pyridine Moiety and Their Antimicrobial Evaluation

Title:A Facile Synthesis and Drug Design of Some New Heterocyclic Compounds Incorporating Pyridine Moiety and Their Antimicrobial Evaluation

Volume: 14 Issue: 7

Author(s): Fathy M. Abdelrazek, Sobhi M. Gomha*, Aly H. Abdelrahman, Peter Metz and Mohsen A. Sayed

Affiliation:

• Chemistry Department, Faculty of Science, Cairo University, Giza 12613,Egypt

Keywords: Acetylpyridine, antimicrobial activity, enaminone, hydrazonyl halides, molecular docking.

Abstract: Background: An efficient synthesis of hitherto unreported 4-heteroarylpyridines was described via regioselective 1,3-dipolar cycloaddition reactions of 3-(dimethylamino)-1-(pyridin-4- yl)prop-2-en-1-one (2) with nitrilimines 4a-h to afford the corresponding pyrazole derivatives 6a-h. Hydrazinolysis of 6a-c,e-f yielded the respective pyrazolopyridazines 7a-f. The enaminone 2 reacts also with 6-aminothiouracil (8) to yielded thione 9. The reaction of 9 with hydrazonoyl chlorides 3 yielded products 13a-h. Pyridine analogs substituted in the 4-position with a pyridinones 18, 20, 22 or naphthofuran 24 were also synthesized. The structures of the newly synthesized compounds were confirmed by spectral data and elemental analyses.

Cite this article as:

Abdelrazek M. Fathy, Gomha M. Sobhi*, Abdelrahman H. Aly, Metz Peter and Sayed A. Mohsen, A Facile Synthesis and Drug Design of Some New Heterocyclic Compounds Incorporating Pyridine Moiety and Their Antimicrobial Evaluation, Letters in Drug Design & Discovery 2017; 14 (7) . https://dx.doi.org/10.2174/1570180814666161128120240