摘要
背景:从遗传学收敛的证据,症状和精神药理学的暗示有精神分裂症的内在联系(SCZ)、双相情感障碍(BPD)和抑郁症(MDD),例如,任何两个甚至三个这些疾病可能在一些家庭并存。 目的:筛选出易感基因位于6号染色体上的全面SCZ,在中国在一个相对同质的群体BPD和MDD。 方法:总共有56.400个单核苷酸多态性(SNPs)6号染色体上的基因的Affymetrix人的全基因组SNP阵列6 119 SCZ,253桶(类型I)、177例抑郁症患者和1000名对照。 结果:相关的SNP位点在染色体6综合显示和突出的易感基因的鉴定包括JARID2(智人十文字,在丰富的互动域2)是胚胎发育的神经管融合过程中的重要作用。不料,侧翼基因的所有相关的单核苷酸多态性在986 SCZ患者扩大队列复制。 结论:考虑到所有的证据,我们的研究结果表明,双相情感障碍和重度抑郁症是精神分裂症的亚型。此外,JARID2是这个群体中一个重要的精神病基因。
关键词: 精神分裂症的亚型,双相情感障碍,抑郁症,JARID2,基因。
Current Molecular Medicine
Title:A Novel Relationship for Schizophrenia, Bipolar and Major Depressive Disorder Part 6: A Hint from Chromosome 6 High Density Association Screen
Volume: 16 Issue: 9
Author(s): X. Chen, F. Long, B. Cai, X.H. Chen, G. Chen
Affiliation:
关键词: 精神分裂症的亚型,双相情感障碍,抑郁症,JARID2,基因。
摘要: Background: Convergent evidence from genetics, symptomatology and psychopharmacology imply that there are intrinsic connections between schizophrenia (SCZ), bipolar disorder (BPD) and major depressive disorder (MDD), for example, any two or even three of these disorders could co-exist in some families.
Objective: To screen out the susceptibility genes on chromosome 6 comprehensively for SCZ, BPD and MDD in a relative homogenous population in China. Method: A total of 56.400 single nucleotide polymorphism (SNPs) on chromosome 6 were genotyped by Affymetrix Genome-Wide Human SNP array 6.0 on 119 SCZ, 253 BPD (type- I), 177 MDD patients and 1000 controls. Results: Associated SNP loci on chromosome 6 were comprehensively revealed and outstanding susceptibility genes were identified including JARID2 (Homo sapiens jumonji, AT rich interactive domain 2) which plays an essential role in embryonic development and neural tube fusion process. Unexpectedly, flanking genes for all associated SNPs were replicated in an enlarged cohort of 986 SCZ patients. Conclusion: Considering all evidence, our results imply that both of bipolar disorder and major depressive disorder are subtypes of schizophrenia. Furthermore, JARID2 is an important psychosis gene in this population.Export Options
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Cite this article as:
X. Chen, F. Long, B. Cai, X.H. Chen, G. Chen , A Novel Relationship for Schizophrenia, Bipolar and Major Depressive Disorder Part 6: A Hint from Chromosome 6 High Density Association Screen, Current Molecular Medicine 2016; 16 (9) . https://dx.doi.org/10.2174/1566524016666161128115135
DOI https://dx.doi.org/10.2174/1566524016666161128115135 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
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