摘要
背景:从遗传学收敛的证据,症状和精神药理学的暗示有精神分裂症的内在联系(SCZ)、双相情感障碍(BPD)和抑郁症(MDD),例如,任何两个甚至三个这些疾病可能在一些家庭并存。 目的:筛选出易感基因位于6号染色体上的全面SCZ,在中国在一个相对同质的群体BPD和MDD。 方法:总共有56.400个单核苷酸多态性(SNPs)6号染色体上的基因的Affymetrix人的全基因组SNP阵列6 119 SCZ,253桶(类型I)、177例抑郁症患者和1000名对照。 结果:相关的SNP位点在染色体6综合显示和突出的易感基因的鉴定包括JARID2(智人十文字,在丰富的互动域2)是胚胎发育的神经管融合过程中的重要作用。不料,侧翼基因的所有相关的单核苷酸多态性在986 SCZ患者扩大队列复制。 结论:考虑到所有的证据,我们的研究结果表明,双相情感障碍和重度抑郁症是精神分裂症的亚型。此外,JARID2是这个群体中一个重要的精神病基因。
关键词: 精神分裂症的亚型,双相情感障碍,抑郁症,JARID2,基因。
Current Molecular Medicine
Title:A Novel Relationship for Schizophrenia, Bipolar and Major Depressive Disorder Part 6: A Hint from Chromosome 6 High Density Association Screen
Volume: 16 Issue: 9
Author(s): X. Chen, F. Long, B. Cai, X.H. Chen, G. Chen
Affiliation:
关键词: 精神分裂症的亚型,双相情感障碍,抑郁症,JARID2,基因。
摘要: Background: Convergent evidence from genetics, symptomatology and psychopharmacology imply that there are intrinsic connections between schizophrenia (SCZ), bipolar disorder (BPD) and major depressive disorder (MDD), for example, any two or even three of these disorders could co-exist in some families.
Objective: To screen out the susceptibility genes on chromosome 6 comprehensively for SCZ, BPD and MDD in a relative homogenous population in China. Method: A total of 56.400 single nucleotide polymorphism (SNPs) on chromosome 6 were genotyped by Affymetrix Genome-Wide Human SNP array 6.0 on 119 SCZ, 253 BPD (type- I), 177 MDD patients and 1000 controls. Results: Associated SNP loci on chromosome 6 were comprehensively revealed and outstanding susceptibility genes were identified including JARID2 (Homo sapiens jumonji, AT rich interactive domain 2) which plays an essential role in embryonic development and neural tube fusion process. Unexpectedly, flanking genes for all associated SNPs were replicated in an enlarged cohort of 986 SCZ patients. Conclusion: Considering all evidence, our results imply that both of bipolar disorder and major depressive disorder are subtypes of schizophrenia. Furthermore, JARID2 is an important psychosis gene in this population.Export Options
About this article
Cite this article as:
X. Chen, F. Long, B. Cai, X.H. Chen, G. Chen , A Novel Relationship for Schizophrenia, Bipolar and Major Depressive Disorder Part 6: A Hint from Chromosome 6 High Density Association Screen, Current Molecular Medicine 2016; 16 (9) . https://dx.doi.org/10.2174/1566524016666161128115135
DOI https://dx.doi.org/10.2174/1566524016666161128115135 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Aptamer-Based Targeted Drug Delivery Systems: Current Potential and Challenges
Current Medicinal Chemistry NUPR1 Interacts with p53, Transcriptionally Regulates p21 and Rescues Breast Epithelial Cells from Doxorubicin-Induced Genotoxic Stress
Current Cancer Drug Targets Nanostructural Hybrid Sensitizers for Photodynamic Therapy
Current Pharmaceutical Design Pathological and Therapeutic Aspects of Long Noncoding RNAs in Osteosarcoma
Anti-Cancer Agents in Medicinal Chemistry Role of the Retinoblastoma Tumor Suppressor in the Maintenance of Genome Integrity
Current Molecular Medicine NF-κB as a Therapeutic Target for Transcription Factor Decoy Strategy in Inflammatory Diseases
Current Medicinal Chemistry - Anti-Inflammatory & Anti-Allergy Agents Developing Histone Deacetylase Inhibitors as Anti-Cancer Therapeutics
Current Medicinal Chemistry Natural Products as Anti-Cancerous Therapeutic Molecules Targeted towards Topoisomerases
Current Protein & Peptide Science Structure, Function, and Pathogenesis of SHP2 in Developmental Disorders and Tumorigenesis
Current Cancer Drug Targets Chemoprevention of Colorectal Cancer: Progress or Pipedream?
Current Cancer Therapy Reviews Secondary Radiation-Induced Bone Tumours Demonstrate a High Degree of Genomic Instability Predictive of a Poor Prognosis
Current Genomics Intercellular Genomic (Chromosomal) Variations Resulting in Somatic Mosaicism: Mechanisms and Consequences
Current Genomics Omega-3 Polyunsaturated Fatty Acids and Cancer
Anti-Cancer Agents in Medicinal Chemistry Cancer: A Problem of Developmental Biology; Scientific Evidence for Reprogramming and Differentiation Therapy
Current Drug Targets Chromatin Remodeling Agents for Cancer Therapy
Reviews on Recent Clinical Trials Epigenetics in Ocular Diseases
Current Genomics Phosphoprotein Phosphatase 1 Complexes in Spermatogenesis
Current Molecular Pharmacology Targeted Therapies in Lung Cancers: Current Landscape and Future Prospects
Recent Patents on Anti-Cancer Drug Discovery RNA Interference (RNAi) Patents and Human Health Related Applications of RNAi
Recent Patents on DNA & Gene Sequences Drug Transporters and Multiple Drug Resistance in the Most Common Pediatric Solid Tumors
Current Drug Metabolism