T细胞在早期生命中的生殖毒性：异常免疫发育和出生后疾病

Title:Reproductive Toxicity of T Cells in Early Life: Abnormal Immune Development and Postnatal Diseases

Volume: 18 Issue: 10

关键词: 免疫毒理学，生殖毒性，T细胞，胸腺细胞，胸腺，免疫疾病。

摘要: Immunity is a balanced status with adequate biological defenses to recognize and fight “non-self”, as well as adequate tolerance to recognize “self”. To maintain this immune homeostasis, a well-organized T cell immune network is required, which in part depends on the well-controlled development of alternative effector T cells, with different cytokine repertoires. Recent researches have pointed that developing fetal T cells network is a remarkably sensitive toxicological target for adverse factors in early life. Epidemiological and experimental studies showed an inseparable relationship between T cell developmental toxicity and immune diseases in adults. Considering that the inflammatory and immune disorders have become a growing health problem worldwide, increasing attention is now being paid to the T cell developmental toxicity. We propose that adverse factors may have programming effects on the crucial functions of immune system during early life which is critical for fetal T cell development and the establishment of the distinct T cell repertoires balance. The permanently disturbed intrathymic or peripheral T cell development may in turn lead to the immune disorders in later life. In this manuscript, we reviewed how adverse factors affected T cell development in early-life with the consequence of the immune dysfunction and immune diseases, and further elucidate the mechanisms. These mechanisms will be helpful in prevention and treatment of the increased prevalence of immune diseases by interfering those pathways.

Cite this article as:

Reproductive Toxicity of T Cells in Early Life: Abnormal Immune Development and Postnatal Diseases, Current Drug Targets 2017; 18 (10) . https://dx.doi.org/10.2174/1389450117666161124145641