Recent Patents on Proteasome Inhibitors of Natural Origin

Title:Recent Patents on Proteasome Inhibitors of Natural Origin

Volume: 12 Issue: 1

Author(s): Daniela Correia da Silva, Paula B. Andrade, Vera Ribeiro, Patricia Valentao and David M. Pereira

Affiliation:

Keywords: Marine-derived natural products, proteasome inhibitors, proteostasis, proteotoxicity, terrestrial-derived natural products, ubiquitin-proteasome system.

Abstract: Background: The proteasome is the major proteolytic site on the eukaryotic cell, degrading most of its short-lived or misfolded polypeptides. The ubiquitin-proteasome pathway has been found to play a fundamental role in the development of several pathologies, from cancer to neurodegenerative diseases, or even retroviral infections. Nature remains a powerful source for the discovery of bioactive compounds. Recently, a number of molecules of natural origin, as well as natural product derivatives, have been described as proteasome inhibitors. Most of these molecules directly block one or more catalytic sites of the 20S proteasome, but some of them act upstream of proteolytic degradation, for instance, inhibiting the ubiquitin tagging process.

Cite this article as:

Silva Correia da Daniela, Andrade B. Paula, Ribeiro Vera, Valentao Patricia and Pereira M. David, Recent Patents on Proteasome Inhibitors of Natural Origin, Recent Patents on Anti-Cancer Drug Discovery 2017; 12 (1) . https://dx.doi.org/10.2174/1574892812666161123142037