Recent Patents on Heat Shock Proteins Targeting Antibodies

Title:Recent Patents on Heat Shock Proteins Targeting Antibodies

Volume: 12 Issue: 1

Author(s): Joao C. Fernandes and Pedro Alves

Affiliation:

Keywords: Antibody, cancer treatment, chaperones, heat-shock proteins, patent.

Abstract: Background: Heat shock proteins (Hsp) are major chaperone molecules that have recently emerged as cancer therapeutic targets owing to their involvement in tumor cell proliferation, differentiation, invasion and metastasis. High levels of extracellular Hsp90 and Hsp70 have been closely associated with a wide range of human cancers. Accumulating evidence suggests that the pharmacological inhibition of these molecules can play a pivotal role in non-surgical cancer treatment. Efforts have been taken to develop monoclonal antibodies (mAbs) and antibody fragments targeting extracellular Hsp90 and Hsp70, alone or conjugated with standard anticancer agents, to control several types of cancer, such as breast, colon, prostate or melanoma.

Cite this article as:

Fernandes C. Joao and Alves Pedro, Recent Patents on Heat Shock Proteins Targeting Antibodies, Recent Patents on Anti-Cancer Drug Discovery 2017; 12 (1) . https://dx.doi.org/10.2174/1574892812666161123141516