儿茶素的抗流感病毒作用：分子和临床综述

Title:Anti-influenza Virus Effects of Catechins: A Molecular and Clinical Review

Volume: 23 Issue: 42

Author(s): Kazuke Ide, Yohei Kawasaki, Koji Kawakami, Hiroshi Yamada

Affiliation:

关键词: 流感，绿茶，儿茶素，生物活性，构效关系，临床研究。

摘要: Influenza infection and associated epidemics represent a serious public health problem. Several preventive and curative measures exist against its spread including vaccination and therapeutic agents such as neuraminidase inhibitors (e.g., oseltamivir, zanamivir, as well as peramivir and laninamivir, which are licensed in several countries) and adamantanes (e.g., amantadine and rimantadine). However, neuraminidase inhibitor- and adamantane- resistant viruses have been detected, whereas vaccines exhibit strain-specific effects and are limited in supply. Thus, new approaches are needed to prevent and treat influenza infections. Catechins, a class of polyphenolic flavonoids present in tea leaves, have been reported as potential anti-influenza virus agents based on experimental and clinical studies. (−)-epigallocatechin gallate (EGCG), a major and highly bioactive catechin, is known to inhibit influenza A and B virus infections in Madin-Darby canine kidney cells. Additionally, EGCG and other catechin compounds such as epicatechin gallate and catechin-5-gallate also show neuraminidase inhibitory activities as demonstrated via molecular docking. These catechins can bind differently to neuraminidase and might overcome known drug resistancerelated virus mutations. Furthermore, the antiviral effects of chemically modified catechin derivatives have also been investigated, and future structure-based drug design studies of catechin derivatives might contribute to improvements in influenza prevention and treatment. This review briefly summarizes probable mechanisms underlying the inhibitory effects of tea catechins against influenza infection and their clinical benefits on influenza prevention and treatment. Additionally, the great potential of tea catechins and their chemical derivatives as effective antiviral agents is described.

Cite this article as:

Kazuke Ide, Yohei Kawasaki, Koji Kawakami, Hiroshi Yamada , Anti-influenza Virus Effects of Catechins: A Molecular and Clinical Review, Current Medicinal Chemistry 2016; 23 (42) . https://dx.doi.org/10.2174/0929867324666161123091010