Engineering Virus-like Particles for Antigen and Drug Delivery

Title:Engineering Virus-like Particles for Antigen and Drug Delivery

Volume: 19 Issue: 1

Author(s): Brett D. Hill, Andrew Zak, Eshita Khera and Fei Wen*

Affiliation:

• Department of Chemical Engineering, University of Michigan, 2800 Plymouth Rd., NCRC B028- G058W, Ann Arbor, MI 48109,United States

Keywords: Virus-like particles, drug delivery, vaccines, epitope, immunity, protein engineering, chemistry, nanoparticles.

Abstract: Virus-like particles (VLPs) are nanoscale biological structures consisting of viral proteins assembled in a morphology that mimic the native virion but do not contain the viral genetic material. The possibility of chemically and genetically modifying the proteins contained within VLPs makes them an attractive system for numerous applications. As viruses are potent immune activators as well as natural delivery vehicles of genetic materials to their host cells, VLPs are especially well suited for antigen and drug delivery applications. Despite the great potential, very few VLP designs have made it through clinical trials. In this review, we will discuss the challenges of developing VLPs for antigen and drug delivery, strategies being explored to address these challenges, and the genetic and chemical approaches available for VLP engineering.

Cite this article as:

Hill D. Brett, Zak Andrew, Khera Eshita and Wen Fei*, Engineering Virus-like Particles for Antigen and Drug Delivery, Current Protein & Peptide Science 2018; 19 (1) . https://dx.doi.org/10.2174/1389203718666161122113041

DOI https://dx.doi.org/10.2174/1389203718666161122113041	Print ISSN 1389-2037
Publisher Name Bentham Science Publisher	Online ISSN 1875-5550