摘要
螺旋体被怀疑与神经疾病的发生有关,包括神经梅毒或神经退行性变(ND)。铁稳态受损与功能丧失有关。几种需要铁作为辅助因子的酶,有毒氧化物种的形成,炎症和β-淀粉样蛋白的增加。本审查建议讨论可能出现的联系。在密螺旋体参与ND的发生或恶化和铁失平衡之间。密螺旋体分泌的蛋白质可直接作用于铁代谢,具有血红素结合能力。(HBPA和HbpB)和铁还原酶能够还原血红素中心铁、含铁蛋白(rubredosin、neelaredosin、硫铁氧还蛋白、细菌铁蛋白等)。特雷Onema还能与细胞化合物相互作用,特别是参与铁代谢的血浆蛋白,从而促进梅毒螺旋体的毒力(例如,轮状体运动和存活)。l)纤维连接蛋白、转铁蛋白和乳铁蛋白也是粘附宿主细胞和细胞外基质的受体。梅毒螺旋体与铁结合蛋白Re的关系在全身和粘膜感染期间,梅毒螺旋体从宿主大分子中积累和隔离铁的结果。
关键词: 失调,铁,炎症,神经退行性疾病,梅毒螺旋体,螺旋体。
Current Alzheimer Research
Title:Treponema, Iron and Neurodegeneration
Volume: 15 Issue: 8
关键词: 失调,铁,炎症,神经退行性疾病,梅毒螺旋体,螺旋体。
摘要: Spirochetes are suspected to be linked to the genesis of neurological diseases, including neurosyphillis or neurodegeneration (ND). Impaired iron homeostasis has been implicated in loss of function in several enzymes requiring iron as a cofactor, formation of toxic oxidative species, inflammation and elevated production of beta-amyloid proteins. This review proposes to discuss the link that may exist between the involvement of Treponema spp. in the genesis or worsening of ND, and iron dyshomeostasis. Proteins secreted by Treponema can act directly on iron metabolism, with hemin binding ability (HbpA and HbpB) and iron reductase able to reduce the central ferric iron of hemin, iron-containing proteins (rubredoxin, neelaredoxin, desulfoferrodoxin metalloproteins, bacterioferritins etc). Treponema can also interact with cellular compounds, especially plasma proteins involved in iron metabolism, contributing to the virulence of the syphilis spirochetes (e.g. treponemal motility and survival). Fibronectin, transferrin and lactoferrin were also shown to be receptors for treponemal adherence to host cells and extracellular matrix. Association between Treponema and iron binding proteins results in iron accumulation and sequestration by Treponema from host macromolecules during systemic and mucosal infections.
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Cite this article as:
Treponema, Iron and Neurodegeneration, Current Alzheimer Research 2018; 15 (8) . https://dx.doi.org/10.2174/1567205013666161122093404
DOI https://dx.doi.org/10.2174/1567205013666161122093404 |
Print ISSN 1567-2050 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5828 |
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