摘要
本综述详细介绍了2015年发布的新型海洋化合物及其合成类似物的最新结构 - 活性关系(SAR)研究,这些化合物具有潜在的或已建立的抗癌活性。作为抗癌药物发现过程的第一步,优先考虑通常使用人类癌细胞系组进行的海洋生物活性化合物体外筛选方法的论文。我们的综述描述了属于不同种类物质的化合物,即萜类化合物,糖苷,生物碱,类固醇以及其他小分子化合物。我们相信,我们的审查不仅将有助于化学家设计和合成在人类癌细胞中具有特异性细胞毒性或细胞抑制活性的新型抗癌化合物,而且还将扩展包括海洋天然化合物生物活性数据的现有数据库。
关键词: 海洋天然化合物,抗癌活性,结构 - 活性关系(SAR)研究,生物碱,甙类,萜类化合物,类固醇。
Current Medicinal Chemistry
Title:Structure-activity Relationship Studies of New Marine Anticancer Agents and their Synthetic Analogues
Volume: 24 Issue: 42
关键词: 海洋天然化合物,抗癌活性,结构 - 活性关系(SAR)研究,生物碱,甙类,萜类化合物,类固醇。
摘要: This review addresses in-depth recent structure-activity relationship (SAR) studies published in 2015 on new marine compounds and their synthetic analogues with potential or established anticancer activity. Priority was given to papers on in vitro screening methods of marine-derived bioactive compounds, usually performed using panels of human cancer cell lines, as a first step of the anticancer drugs discovery process. Our review describes compounds belonging to different classes of substances, namely terpenoids, glycosides, alkaloids, steroids, as well as other small molecular compounds. We believe that our review will not only help chemists in the design and synthesis of novel anticancer compounds possessing specific cytotoxic or cytostatic activity in human cancer cells, but will also extend the existing databases comprising data on bioactivity of marine natural compounds.
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Cite this article as:
Structure-activity Relationship Studies of New Marine Anticancer Agents and their Synthetic Analogues, Current Medicinal Chemistry 2017; 24 (42) . https://dx.doi.org/10.2174/0929867324666161121115404
DOI https://dx.doi.org/10.2174/0929867324666161121115404 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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