摘要
糖原磷酸化(GP)是一种有效的药物靶点的抗高血糖药物的发展。植物多酚,主要是黄酮和五环三萜类化合物,已发现的GP的强效抑制剂。这些化合物具有药品和保健品在2型糖尿病血糖控制的潜力。这次综述的重点主要是最成功的(有效的)发现这些化合物的日期。蛋白质-配体相互作用,形成自己的能力结构的基础上进行了讨论,并在未来新的GP抑制剂设计的支架的开发潜力。
关键词: α-葡萄糖苷酶,抗氧化剂,糖尿病,糖原磷酸化酶,黄酮,五环三萜。
Current Medicinal Chemistry
Title:Phytogenic Polyphenols as Glycogen Phosphorylase Inhibitors: The Potential of Triterpenes and Flavonoids for Glycaemic Control in Type 2 Diabetes
Volume: 24 Issue: 4
关键词: α-葡萄糖苷酶,抗氧化剂,糖尿病,糖原磷酸化酶,黄酮,五环三萜。
摘要: Glycogen phosphorylase (GP) is a validated pharmaceutical target for the development of antihyperglycaemic agents. Phytogenic polyphenols, mainly flavonoids and pentacyclic triterpenes, have been found to be potent inhibitors of GP. These compounds have both pharmaceutical and nutraceutical potential for glycemic control in diabetes type 2. This review focuses mainly on the most successful (potent) of these compounds discovered to date. The protein-ligand interactions that form the structural basis of their potencies are discussed, highlighting the potential for exploitation of their scaffolds in the future design of new GP inhibitors.
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Phytogenic Polyphenols as Glycogen Phosphorylase Inhibitors: The Potential of Triterpenes and Flavonoids for Glycaemic Control in Type 2 Diabetes, Current Medicinal Chemistry 2017; 24 (4) . https://dx.doi.org/10.2174/0929867324666161118122534
DOI https://dx.doi.org/10.2174/0929867324666161118122534 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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