Sulfamic Acid-catalyzed One-pot Multicomponent Synthesis of 5-phenyl-2- thioxo-1,2,3,5-tetrahydro-4H-pyrimido[4,5-d][1,3]thiazolo[3,2-a]pyrimidin- 4-ones

Title:Sulfamic Acid-catalyzed One-pot Multicomponent Synthesis of 5-phenyl-2- thioxo-1,2,3,5-tetrahydro-4H-pyrimido[4,5-d][1,3]thiazolo[3,2-a]pyrimidin- 4-ones

Volume: 3 Issue: 3

Author(s): Sunetra Jadhav, Ajinkya Patravale, Reshma Patil, Digambar Kumbhar, Vishram Karande, Dattatray Chandam and Madhukar Deshmukh*

Affiliation:

• Department of Agrochemicals and Pest Management, Shivaji University, Kolhapur, M.S.,India

Keywords: 2-Aminothiazole, 2-thiobarbituric acid, thiazolopyrimidine derivatives, sulfamic acid, atom economy, multicomponent reaction.

Abstract: Background: A straightforward protocol for the one-pot synthesis of a series of novel thiazolopyrimidine derivatives has been developed.

Method: In which multicomponent reaction between thiobarbituric acid, 2-aminothiozole and several substituted aldehydes using sulfamic acid (20 mol%) as a heterogeneous and easily recoverable catalyst in ethanol under reflux condition.

Conclusion: This method has several advantages like greener synthetic approach, good to excellent yield (82-91%), cost-effectiveness, easy work-up and atom-economic procedure.

Cite this article as:

Jadhav Sunetra, Patravale Ajinkya, Patil Reshma, Kumbhar Digambar, Karande Vishram, Chandam Dattatray and Deshmukh Madhukar*, Sulfamic Acid-catalyzed One-pot Multicomponent Synthesis of 5-phenyl-2- thioxo-1,2,3,5-tetrahydro-4H-pyrimido[4,5-d][1,3]thiazolo[3,2-a]pyrimidin- 4-ones, Current Green Chemistry 2016; 3 (3) . https://dx.doi.org/10.2174/2213346103666161115124757

DOI https://dx.doi.org/10.2174/2213346103666161115124757	Print ISSN 2213-3461
Publisher Name Bentham Science Publisher	Online ISSN 2213-347X