Abstract
For a body of work to eventually be designated as a “Landmark” article may require years of analysis, further investigative support, and frequent citations in future articles. In this issue of Current Neurovascular Research, we are introducing the publication of pioneering original articles in combination with “state-of the-art” review articles that may someday be considered significant building blocks for future lines of investigation. In several respects, the articles focus upon the ability of ischemic cell injury to not only lead to acute or chronic nervous system impairment in a variety of disorders, but also to actively generate reparative processes that may even result from activities considered as simple as physical exercise.