Dual Approach of Nanoemulsion and Natural Permeation Enhancer Endorse Skin Targeting of Acyclovir

Title:Dual Approach of Nanoemulsion and Natural Permeation Enhancer Endorse Skin Targeting of Acyclovir

Volume: 13 Issue: 2

Author(s): Mukta Singh, Lakhvir Kaur, Harmanpreet Singh, Nikhil Shri Sahajpal, Harjeet Singh and Subheet Kumar Jain

Affiliation:

Keywords: Acyclovir, localization index, local bioavailability, nanoemulsion based gel, rheological characterization, skin deposition study.

Abstract: Background: In this study, nanoemulsion based gel formulation of acyclovir was prepared in order to increase its topical effectiveness and target the disease site, which is the foremost limitation associated with the topical marketed formulations of acyclovir.

Methods: In this study, nanoemulsion based gel formulation of acyclovir was prepared in order to increase its topical effectiveness and target the disease site, which is the foremost limitation associated with the topical marketed formulations of acyclovir. A w/o nanoemulsion in the strength of 5%w/w was prepared using probe sonication method and was characterized extensively in vitro, ex vivo and in vivo to determine the quantity of drug that reached into skin to effectively treat the disease.

Results: Skin deposition across the rat skin was found to be 6.6 fold higher with developed nanoemulsion based gel formulation in comparison to the marketed cream. The results of enhanced skin permeation and deposition were deep-rooted by carrying out different mechanistic studies like FTIR and CLSM of skin treated with prepared formulation. The rheological characterization study depicted the shear thinning property and better structural recovery of nanoemulsion based gel (99.17±1.1%) as compared to marketed cream (95.03±0.8%). Further in-vivo localization index, which was found to be 60.33±0.9% and 19.21±0.6% for prepared gel and marketed cream, respectively, assured high skin deposition and adequate penetration of the prepared gel to the different layers of skin with no significant absorption into the systemic circulation.

Conclusion: Higher drug solubility, lower particle size, higher surface area and enhanced skin permeation and deposition associated with prepared formulation seems to be responsible for its elevated skin penetration which makes developed w/o nanoemulsion based gel as effective carrier for increasing the local bioavailability of acyclovir.

Cite this article as:

Singh Mukta, Kaur Lakhvir, Singh Harmanpreet, Sahajpal Shri Nikhil, Singh Harjeet and Jain Kumar Subheet, Dual Approach of Nanoemulsion and Natural Permeation Enhancer Endorse Skin Targeting of Acyclovir, Current Nanoscience 2017; 13 (2) . https://dx.doi.org/10.2174/1573413713666161108115740

DOI https://dx.doi.org/10.2174/1573413713666161108115740	Print ISSN 1573-4137
Publisher Name Bentham Science Publisher	Online ISSN 1875-6786