Abstract
Background: ‘Beta thalassemia is inherited hemoglobin disorder resulting in chronic hemolytic anemia that requires lifelong transfusion therapy’. ‘Repeated blood transfusions and RBCs hemolysis are the main causes of iron overload’, which in addition to immune abnormalities, are common predisposing factors to infections in patients with thalassemia.
The Aim of this Work: The aim of this work was to study immune status including T lymphocyte subsets and serum immunoglobulin levels ‘in children with beta- thalassemia in correlation with iron overload’. Patients and Methods: The present ‘study was conducted on 40 children with beta thalassemia major under follow up at Hematology Unit, Pediatric Department, Tanta University’ ‘including 24 males and 16 females with mean’ age value of 9. 22 ± 3.9 years and 20 ‘healthy children of matched age and sex as a control group’. All children included in the study were subjected to; ‘complete blood count, Hb electrophoresis, serum iron status’, T cell subsets including CD3, CD4 and CD8 and serum immunoglobulin levels including IgM, IgA and IgG. Results: ‘Pallor and jaundice were the most common presenting’ clinical manifestations. Infective episodes ‘were significantly higher in patients’ compared with controls. There were significantly lower Hb, MCV and MCH levels and significantly higher WBCs and platelets counts, reticulocytes and lymphocytes percentage in patients than controls and no significant differences in MCHC between patients and controls. Serum ferritin and iron were ‘significantly higher but TIBC was significantly lower in’ patients than controls. CD3, CD4 and IgM were significantly lower but CD8, IgG, and IgA ‘were significantly higher in patients than controls’ with negative correlation between CD3, CD4, IgM and ferritin and positive correlation between CD8, IgG, IgA and ferritin. Conclusion: Iron overload can affect humeral and cell mediated immunity in patients with beta thalassemia with reduction of IgM, CD3 and CD4 and elevation of CD8, IgG, and IgA. Recommendations: Regular follow up of patients with beta thalassemia for detection of iron overload as it affects humeral and cell mediated immunity.Keywords: Beta thalassemia, iron overload, serum immunoglobulin levels, T lymphocyte subsets.
Graphical Abstract
Endocrine, Metabolic & Immune Disorders - Drug Targets
Title:Immune Status 'in Children with Beta Thalassemia' in Correlation 'with Iron Overload': Single Center Egyptian Study
Volume: 16 Issue: 3
Author(s): Adel A. Hagag, Mohamed A. Elgamsy, Hassan M. El-Asy, Rasha M. Gamal, Walid N. Elshahaby and Enaam S. Abd Elbar
Affiliation:
Keywords: Beta thalassemia, iron overload, serum immunoglobulin levels, T lymphocyte subsets.
Abstract: Background: ‘Beta thalassemia is inherited hemoglobin disorder resulting in chronic hemolytic anemia that requires lifelong transfusion therapy’. ‘Repeated blood transfusions and RBCs hemolysis are the main causes of iron overload’, which in addition to immune abnormalities, are common predisposing factors to infections in patients with thalassemia.
The Aim of this Work: The aim of this work was to study immune status including T lymphocyte subsets and serum immunoglobulin levels ‘in children with beta- thalassemia in correlation with iron overload’. Patients and Methods: The present ‘study was conducted on 40 children with beta thalassemia major under follow up at Hematology Unit, Pediatric Department, Tanta University’ ‘including 24 males and 16 females with mean’ age value of 9. 22 ± 3.9 years and 20 ‘healthy children of matched age and sex as a control group’. All children included in the study were subjected to; ‘complete blood count, Hb electrophoresis, serum iron status’, T cell subsets including CD3, CD4 and CD8 and serum immunoglobulin levels including IgM, IgA and IgG. Results: ‘Pallor and jaundice were the most common presenting’ clinical manifestations. Infective episodes ‘were significantly higher in patients’ compared with controls. There were significantly lower Hb, MCV and MCH levels and significantly higher WBCs and platelets counts, reticulocytes and lymphocytes percentage in patients than controls and no significant differences in MCHC between patients and controls. Serum ferritin and iron were ‘significantly higher but TIBC was significantly lower in’ patients than controls. CD3, CD4 and IgM were significantly lower but CD8, IgG, and IgA ‘were significantly higher in patients than controls’ with negative correlation between CD3, CD4, IgM and ferritin and positive correlation between CD8, IgG, IgA and ferritin. Conclusion: Iron overload can affect humeral and cell mediated immunity in patients with beta thalassemia with reduction of IgM, CD3 and CD4 and elevation of CD8, IgG, and IgA. Recommendations: Regular follow up of patients with beta thalassemia for detection of iron overload as it affects humeral and cell mediated immunity.Export Options
About this article
Cite this article as:
Hagag A. Adel, Elgamsy A. Mohamed, El-Asy M. Hassan, Gamal M. Rasha, Elshahaby N. Walid and Abd Elbar S. Enaam, Immune Status 'in Children with Beta Thalassemia' in Correlation 'with Iron Overload': Single Center Egyptian Study, Endocrine, Metabolic & Immune Disorders - Drug Targets 2016; 16 (3) . https://dx.doi.org/10.2174/1871530317666161107160213
DOI https://dx.doi.org/10.2174/1871530317666161107160213 |
Print ISSN 1871-5303 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3873 |

- Author Guidelines
- Bentham Author Support Services (BASS)
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Ion Transporters in Brain Tumors
Current Medicinal Chemistry A Focus on Pharmacological Management of Catecholaminergic Polymorphic Ventricular Tachycardia
Mini-Reviews in Medicinal Chemistry Approaches to the Pharmacological Modulation of Plasmacytoid Dendritic Cells
Endocrine, Metabolic & Immune Disorders - Drug Targets Targeting SUMOylation Cascade for Diabetes Management
Current Drug Targets Gold Nanomaterials: From Preparation to Pharmaceutical Design and Application
Current Pharmaceutical Design Medicinal Agents in the Metabolic Syndrome
Cardiovascular & Hematological Agents in Medicinal Chemistry Mechanical Methods for Dry Particle Coating Processes and Their Applications in Drug Delivery and Development
Recent Patents on Drug Delivery & Formulation Interferon-Beta Therapy Monitoring in Multiple Sclerosis Patients
Endocrine, Metabolic & Immune Disorders - Drug Targets Evaluation of Anti-Diabetic Potential of Corn Silk in High-Fat Diet/ Streptozotocin-Induced Type 2 Diabetes Mice Model
Endocrine, Metabolic & Immune Disorders - Drug Targets Apolipoprotein A5: Extracellular and Intracellular Roles in Triglyceride Metabolism
Current Drug Targets A Piece of the ROCK: A Critical Role for Rho Kinases in the Nervous System
Current Neurovascular Research Genetic Polymorphism and Tumor Immunotherapy
Current Pharmacogenomics Human Platelet-Derived Growth Factor Enhances Healing of Ulcers Situated on Non-Foot Sites in Diabetics. A Pilot Study
Current Drug Therapy Future Therapeutic Directions: New Medications and Insulin Delivery in a Changing World for Effective Diabetes Management
Current Drug Discovery Technologies Nanotechnology in Insulin Delivery for Management of Diabetes
Pharmaceutical Nanotechnology Advancement in Obesity Management: Leptin and Adiponectin Patents
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery (Discontinued) Diabetes Mellitus and SARS-CoV-2 Infection: Pathophysiologic Mechanisms and Implications in Management
Current Diabetes Reviews The Paradox of Oestradiol-Induced Breast Cancer Cell Growth and Apoptosis
Current Signal Transduction Therapy COVID-19: An Update on Pathogenesis and Treatment
Current Pharmaceutical Design Extrinsic Factors Promoting Insulin Producing Cell-Differentiation and Insulin Expression Enhancement-Hope for Diabetics.
Current Stem Cell Research & Therapy