摘要
Kupffer细胞(KC)是参与多种代谢状态的肝脏重要的先天免疫系统的细胞。虽然一些研究直接评估细胞在肝脏中的代谢情况的不同作用,KC一定特征仍然未知。KC耗尽技术被用来确定在代谢挑战KC功能;然而,有关于他们的确切作用,即使成功消融的辩论。而一些KC消融的研究表明胰岛素抵抗的改善,脂肪肝和代谢参数,其他报道,在类似的条件下,没有。一些研究合理的KCS双重作用在肝代谢状态的争论他们的M1和M2的偏见。激活M1 KC分泌促炎症细胞因子、生长因子和其他介质产生炎症应激引发炎症信号在肝细胞破坏的代谢情况。相反,M2 KC产生抗炎细胞因子和炎症介质改善肝脏内的葡萄糖和脂质代谢状态。不幸的是,M1、M2的偏见不提供可靠的解释为KCS耗尽显示截然不同的结果。尽管有很多关于这一主题的研究,这些研究的全面检讨不足。本文试图解决在脂质代谢中的作用”的相关问题。本文不仅警告未来的研究,仔细分析,从KC对脂质代谢的影响还建议评价动物模型和KC耗尽技术作为一个同样重要的辅因子的结果。
关键词: 枯否细胞,immunometabolic,肝脏代谢,消融模型,胰岛素抵抗,脂肪肝。
Current Molecular Medicine
Title:The Duality of Kupffer Cell Responses in Liver Metabolic States
Volume: 16 Issue: 9
Author(s): X. Liu, L. Yu, W. Hassan, L. Sun, L. Zhang, Z. Jiang
Affiliation:
关键词: 枯否细胞,immunometabolic,肝脏代谢,消融模型,胰岛素抵抗,脂肪肝。
摘要: Kupffer cells (KCs) are vital innate immune system cells in the liver that participate in various metabolic states. Although several studies have directly evaluated the role of KCs in different metabolic situations in the liver, the definite characteristics of KCs remain unknown. KC depletion techniques are used to determine the functions of KCs under metabolic challenges; however, there is debate about their precise role even after successful ablation. While some KC ablation studies showed improvement in insulin resistance, fatty liver and metabolic parameters, other reports, under the similar conditions, have not. Some studies have rationalized the KCs dual actions in liver metabolic states by arguing their M1 and M2 biases. Activated M1 KCs secrete pro-inflammatory cytokines, growth factors and other mediators to create inflammatory stress which initiates inflammatory signalling in hepatocytes to disrupt the metabolic scenario. In contrast, M2 KCs generate anti-inflammatory cytokines and mediators which improve glucose and lipid metabolic states within the liver. Unfortunately, the M1/M2 bias does not provide reliable explanation as KCs depletion shows strikingly different results. Despite many investigational studies on this topic, a comprehensive review of these studies is lacking. This review attempts to address the issues related with the dichotomy of KCs effects in lipid metabolism. This review not only warns the future studies to carefully analyze the results that are drawn from KCs effects on lipid metabolism but also suggest to evaluate animal models and KCs depletion techniques as an equally important cofactor.
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Cite this article as:
X. Liu, L. Yu, W. Hassan, L. Sun, L. Zhang, Z. Jiang , The Duality of Kupffer Cell Responses in Liver Metabolic States, Current Molecular Medicine 2016; 16 (9) . https://dx.doi.org/10.2174/1566524016666161031143724
DOI https://dx.doi.org/10.2174/1566524016666161031143724 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
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