摘要
从历史上来说,癌症是从拉丁癌症中得出的,因为肿瘤附近的红色肿胀动脉提醒了医生Galenus和他的罗马人的红蟹。目前,癌症仍然是全球疾病(WHO)的主要死因。肿瘤不仅仅由癌细胞组成,因为它们可以募集正常的细胞,这将形成肿瘤相关基质。这些基质细胞与细胞外基质一起构成肿瘤微环境。肿瘤相关基质细胞与癌细胞之间的相互交流对于诱导上皮 - 间质转化和侵袭是重要的。这种沟通的详细知识可以引发新颖的治疗策略的发展,旨在解决侵入和转移的未被调节的调节因子。因此,这一审查将不仅关注上皮间质转化和侵袭,而且还将关注肿瘤细胞,特别是结肠癌细胞及其基质之间的沟通,以原始关注癌症相关的成纤维细胞,最后这个评论将讨论这种通信如何影响癌细胞入侵其周围环境并形成转移的能力。
关键词: 癌症,肌成纤维细胞,癌相关成纤维细胞,结肠癌,细胞外基质,细胞间通讯,侵袭,肿瘤微环境
图形摘要
Current Drug Targets
Title:When Neighbors Talk: Colon Cancer Cell Invasion and Tumor Microenvironment Myofibroblasts
Volume: 18 Issue: 8
关键词: 癌症,肌成纤维细胞,癌相关成纤维细胞,结肠癌,细胞外基质,细胞间通讯,侵袭,肿瘤微环境
摘要: Historically, the word cancer is derived from the Latin cancer, as the red swollen arteries near a tumor reminded the physician Galenus and his fellow Romans of a red crab. Currently, cancer remains the disease to beat as it remains a leading cause of death worldwide (WHO). Tumors do not simply consist of cancer cells, as they can recruit normal cells, which will form the tumor-associated stroma. These stromal cells together with the extracellular matrix, constitute the tumor microenvironment. Reciprocal communication between tumor-associated stromal cells and cancer cells is important for the induction of epithelial-to-mesenchymal transition and invasion. A detailed knowledge of this communication can spark the development of novel therapeutic strategies aimed at tackling yet unaddressed regulators of invasion and thus metastasis. Therefore, this review will focus not only on epithelial-to-mesenchymal transition and invasion, but also on communication between tumor cells, in particular colon cancer cells, and their stroma, with a primordial focus on cancer-associated fibroblasts, and lastly this review will discuss how this communication can affect the cancer cell’s ability to invade its surroundings and form metastases.
Export Options
About this article
Cite this article as:
When Neighbors Talk: Colon Cancer Cell Invasion and Tumor Microenvironment Myofibroblasts, Current Drug Targets 2017; 18 (8) . https://dx.doi.org/10.2174/1389450117666161028142351
DOI https://dx.doi.org/10.2174/1389450117666161028142351 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
Related Books
![](/images/wayfinder.jpg)
- Author Guidelines
- Bentham Author Support Services (BASS)
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Peripheral Benzodiazepine Receptor (PBR) New Insight in Cell Proliferation and Cell Differentiation Review
Current Clinical Pharmacology In silico Modeling Studies of 5-HT2B Antagonistic Activity of 2-(2- phenylethyl)chromone Derivatives from Cucumis melo Seeds
Letters in Drug Design & Discovery Role of Translocator Protein in Renal Ischemia Reperfusion, Renal Preservation and Acute Kidney Injury
Current Molecular Medicine The Role of Natural Products in the Discovery of New Drug Candidates for the Treatment of Neurodegenerative Disorders I: Parkinsons Disease
CNS & Neurological Disorders - Drug Targets <sup>68</sup>Ga-labeled HBED-CC Variant of uPAR Targeting Peptide AE105 Compared with <sup>68</sup>Ga-NODAGA-AE105
Anti-Cancer Agents in Medicinal Chemistry Meet Our Editorial Board Member
Protein & Peptide Letters Mucopolysaccharidosis Type III (Sanfilippo Syndrome): Emerging Treatment Strategies
Current Pharmaceutical Biotechnology MicroRNAs: Key Players in Microglia and Astrocyte Mediated Inflammation in CNS Pathologies
Current Medicinal Chemistry Hemichannels in the Neurovascular Unit and White Matter Under Normal and Inflamed Conditions
CNS & Neurological Disorders - Drug Targets Flavonoid Kaempferol Inhibits the Proliferation and Survival of Human Leukemia HL60 Cells
Current Drug Therapy Uridine Function in the Central Nervous System
Current Topics in Medicinal Chemistry Melatonin and Melatonin Agonists as Adjunctive Treatments in Bipolar Disorders
Current Pharmaceutical Design Molecular Imaging of Therapeutic Potential of Reporter Probes
Current Drug Targets Macrophage Derived Cystatin B/Cathepsin B in HIV Replication and Neuropathogenesis
Current HIV Research Notch Signalling Pathways and Their Importance in the Treatment of Cancers
Current Drug Targets PDGF/PDGFR Signaling and Targeting in Cancer Growth and Progression: Focus on Tumor Microenvironment and Cancer-associated Fibroblasts
Current Pharmaceutical Design Applications of Nanosystems to Anticancer Drug Therapy (Part II. Dendrimers, Micelles, Lipid-based Nanosystems)
Recent Patents on Anti-Cancer Drug Discovery 7-Keto-Δ5-Steroids: Key-Molecules Owning Particular Biological and Chemical Interest
Mini-Reviews in Medicinal Chemistry The Bacterial lux Reporter System: Applications in Bacterial Localisation Studies
Current Gene Therapy Extracorporeal Shock Wave Therapy in Inflammatory Diseases: Molecular Mechanism that Triggers Anti-Inflammatory Action
Current Medicinal Chemistry