Abstract
Background: A series of new symmetric disulfonamide and dicarbamate derivatives of 4,4ˈ- oxydianiline were designed and synthesized in a simple method. These compounds were characterized by IR, 1H, 13C-NMR, mass spectral data and elemental analysis.
Method: The compounds were screened for their in vitro antibacterial and antifungal activities against various pathogenic organisms. Among the title compounds 10f, 10a and 10h showed promising antibacterial activity and 10g, 10d and 10a showed good antifungal activity. Conclusion: The results also emphasized that the disulfonamide derivatives were better antibacterial agents than the corresponding dicarbamate derivatives.Keywords: 4, 4'-oxydianiline, disulfonamides, false metabolite, dicarbamates, sulphorhodamine-B (SRB) assay method, antibacterial activity, antifungal activity.
Graphical Abstract
Anti-Infective Agents
Title:Design, Synthesis, Characterization and Bioactivity Evaluation of New Symmetric Disulfonamides and Dicarbamates of 4,4'-Oxydianiline
Volume: 15 Issue: 1
Author(s): Pulluru Hari Babu, Chamarthi Naga Raju*, A. Narasimhulu Chetty, P. V. Chalapathi, P. Sreenivasa Murthy and M. Nagalakshmi Devamma
Affiliation:
- Department of Chemistry, Faculty of Sciences, Sri Venkateswara University, Tirupati, India; P.O. Box: 517 502,India
Keywords: 4, 4'-oxydianiline, disulfonamides, false metabolite, dicarbamates, sulphorhodamine-B (SRB) assay method, antibacterial activity, antifungal activity.
Abstract: Background: A series of new symmetric disulfonamide and dicarbamate derivatives of 4,4ˈ- oxydianiline were designed and synthesized in a simple method. These compounds were characterized by IR, 1H, 13C-NMR, mass spectral data and elemental analysis.
Method: The compounds were screened for their in vitro antibacterial and antifungal activities against various pathogenic organisms. Among the title compounds 10f, 10a and 10h showed promising antibacterial activity and 10g, 10d and 10a showed good antifungal activity. Conclusion: The results also emphasized that the disulfonamide derivatives were better antibacterial agents than the corresponding dicarbamate derivatives.Export Options
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Cite this article as:
Babu Hari Pulluru, Raju Naga Chamarthi*, Chetty Narasimhulu A., Chalapathi V. P., Murthy Sreenivasa P. and Devamma Nagalakshmi M., Design, Synthesis, Characterization and Bioactivity Evaluation of New Symmetric Disulfonamides and Dicarbamates of 4,4'-Oxydianiline, Anti-Infective Agents 2017; 15 (1) . https://dx.doi.org/10.2174/2211352514666161028112059
DOI https://dx.doi.org/10.2174/2211352514666161028112059 |
Print ISSN 2211-3525 |
Publisher Name Bentham Science Publisher |
Online ISSN 2211-3533 |
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