摘要
克罗恩病(CD)和溃疡性肠(UC)被分类为以维生素D途径相关的环境和基因因素的多方面病因相关的炎症性肠病(IBD)。在先天免疫抵御机制中功能障碍在肠道的上皮隔层从IBD的病理学角度来看起着关键的作用。IBD所表现的症状是由于机体对肠道细胞的过度免疫应答,以及维生素D在肠道防御中起着重要的角色,它能够通过帮助抑制微生物入侵上皮细胞。维生素D作为免疫调节剂能够修饰机体的先天免疫应答。维生素D可使IBD患者被上皮应激上调的促炎细胞因子的转录衰弱。在82%的IBD患者中检测到维生素D缺乏,而全国平均水平为31%,并且与基因组和蛋白组学水平上的有缺陷的上皮细胞有关。粘膜损伤和免疫反应受损是IBD的主要症状,并且维生素D有助于维持维持上皮细胞的结构完整性,同时加强粘膜的先天免疫应答。在此,我们介绍了一种系统性陈述关于在维生素D缺乏的情况下IBD中细胞因子的病理生理作用。此外,维生素D在调节免疫病理因素如细胞因子、生长因子以及人防御素中免疫调节剂影响的分析将增强维生素D在IBD中的治疗作用的潜在分子机制的了解,从而有助于开发更好的患者管理策略。
关键词: 维生素D,炎性肠病,生物制剂,抗炎治疗,免疫抑制剂,微生物入侵,人防御素,肠道健康,克罗恩病,溃疡性肠
Current Medicinal Chemistry
Title:Interplay of Immunity and Vitamin D: Interactions and Implications with Current IBD Therapy
Volume: 24 Issue: 9
关键词: 维生素D,炎性肠病,生物制剂,抗炎治疗,免疫抑制剂,微生物入侵,人防御素,肠道健康,克罗恩病,溃疡性肠
摘要: Crohn's disease (CD) and ulcerative colitis (UC) are classified under inflammatory bowel disease (IBD) which has been linked to a multifaceted etiology involving both environmental and genetic factors that intersect with the vitamin D pathway. Dysfunctions in innate immune defense mechanisms in the epithelial compartment of the intestine play a crucial role in the pathogenesis of IBD. Symptoms of IBD are caused by excessive immune responses to luminal bacteria, and vitamin D has been shown to play a role in intestinal defense by aiding in the suppression of microbial invasion into the epithelium. Vitamin D, as an immunomodulator, can modify the innate immune response of the body. Vitamin D attenuates the transcription of pro-inflammatory cytokines that are upregulated in the event of epithelial stress common in patients with IBD. Vitamin D deficiency was identified in 82% of IBD patients compared to the 31% national average and has been linked to defective epithelial processes at both genomic and proteomic levels. Mucosal damage and an impaired immune response are at the center of IBD, and vitamin D aids in sustaining the structural integrity of epithelial cells while enhancing innate immune responses in the mucosa. Here we provide a systematic review of the pathophysiological effects of cytokines in IBD in the presence of vitamin D deficiency. Also, analysis of the immunomodulatory effect of vitamin D in regulating immunopathogenic factors like chemokines, growth factors, and human defensins will enhance knowledge of the underlying molecular mechanisms of the therapeutic role of vitamin D in IBD and thus aid in the development of better patient management strategies.
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Interplay of Immunity and Vitamin D: Interactions and Implications with Current IBD Therapy, Current Medicinal Chemistry 2017; 24 (9) . https://dx.doi.org/10.2174/0929867323666161026124951
DOI https://dx.doi.org/10.2174/0929867323666161026124951 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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