微波辅助合成生物相关的吲哚类化合物

Title:Microwave Assisted Synthesis of Biorelevant Benzazoles

Volume: 24 Issue: 41

关键词: 2-氨基苯硫酚，邻苯二胺，羧酸，醛，苯并恶唑，苯并噻唑，苯并咪唑，双杂环骨架，稠环体系，生物活性，无催化剂反应，无溶剂反应，固体载体，常规加热，微波辐射，多组分反应，一锅反应，多米诺反应，迈克尔反应，绿色化学等。

摘要: The benzazole scaffolds are present in various therapeutic agents and have been recognized as the essential pharmacophore for diverse biological activities. These have generated interest and necessity to develop efficient synthetic methods of these privileged classes of compounds to generate new therapeutic leads for various diseases. The biological activities of the benzazoles and efforts towards their synthesis have been summarized in a few review articles. In view of these, the aim of this review is to provide an account of the developments that have taken place in the synthesis of biorelevant benzazoles under microwave irradiation as the application of microwave heating has long been recognized as a green chemistry tool for speedy generation of synthetic targets. Attention has been focused to those literature reports wherein the use of microwave irradiation is the key step in the formation of the heterocyclic ring system or in functionalization of the benzazole ring system to generate the essential pharmacophoric feature. The convenient and economic way to synthesize these privileged class of heterocycles through the use of microwave irradiation that would be beneficial for the drug discovery scientist to synthesize biologically active benzazoles and provide access to wide range of reactions for the synthesis of benzazoles constitute the theme of this review. Examples have been drawn wherein the use of microwave heating offers distinct advantage in terms of improved product yields and reduction of reaction time as compared to those observed for the synthesis under conventional heating.

Cite this article as:

Microwave Assisted Synthesis of Biorelevant Benzazoles, Current Medicinal Chemistry 2017; 24 (41) . https://dx.doi.org/10.2174/0929867323666161025142005