摘要
哺乳动物繁殖是一个复杂的现象。人类的生殖力受环境暴露于有毒物质和营养物质的影响很大。 环境刺激的负担很重,多方面。 污染源很多,通常是隐蔽的,目前,对生态系统和人类健康的广泛的积极和消极后果只有部分被理解。 仅从工业制造,农药,废物积聚和燃烧产生的化合物污染物日常影响人类生活的一些例子。 子宫和睾丸生物学,原始生殖细胞和配子发生是大量污染物的主要目标。 怀孕是每个人和他的后代健康的产后生活的基础。 在产前发展过程中,遗传和表观遗传因素一致,以确定妊娠良好最终结果的良好事件顺序。 动物模型的全球流行病学研究和重点实验揭示了正常和异常发育的分子基础。 关于妊娠状况与成人生活中代谢和其他复杂疾病发病之间关系的证据越来越多。 表观遗传学机制,包括DNA甲基化,组蛋白标记和非编码RNA,是正常发育的主要分子参与者和产后生命期间的适应反应。
关键词: 环境,化学品,基因表达调控,繁殖,DNA甲基化和去甲基化,复杂疾病。
图形摘要
Current Drug Targets
Title:Epigenetic Effects of Environmental Chemicals on Reproductive Biology
Volume: 18 Issue: 10
关键词: 环境,化学品,基因表达调控,繁殖,DNA甲基化和去甲基化,复杂疾病。
摘要: Mammalian reproduction is a complex phenomenon. Human fertility is highly impacted from environmental exposure to toxicants as well as nutrients. The burden of environmental stimuli is heavy and multifaceted. The contaminant sources are many, often occult, and at present, the wide range of positive and negative consequences on the ecosystem and the human health is only partially understood. Compounds deriving from industrial manufacturing, pesticides, waste accumulation and burning are only some examples of the contaminants daily impacting human life. Ovary and testis biology, primordial germinal cells and gametogenesis are primary targets of a large number of pollutants. Pregnancy holds the basis of the healthy post-natal life of each individual and his offspring. During the pre-natal development, genetic and epigenetic factors concur to determine the good sequence of events for the good final outcome of the pregnancy. Worldwide epidemiological studies and focused experiments in animal models are unraveling the molecular basis of the normal and abnormal development. Evidences are growing about the relationship between pregnancy conditions and the onset of metabolic and other complex diseases in adult life. Epigenetic mechanisms, including DNA methylation, histone marks and non coding RNAs, are main molecular players of normal development and of the adaptive response during pre- and post-natal life.
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Cite this article as:
Epigenetic Effects of Environmental Chemicals on Reproductive Biology, Current Drug Targets 2017; 18 (10) . https://dx.doi.org/10.2174/1389450117666161025100125
DOI https://dx.doi.org/10.2174/1389450117666161025100125 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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