摘要
丛生蛋白是一种糖蛋白,参与了许多过程,包括细胞凋亡,细胞周期调控和DNA损伤修复。自从丛生蛋白表达与肿瘤及各种恶性肿瘤有关,包括普遍的肿瘤如前列腺癌,结肠癌进展,膀胱癌和乳腺癌,这种蛋白质已被提议作为一个对未来治疗的很好的候选产品。 已经有大量的研究在细胞和移植瘤模型成功的结果,在一般情况下,认为丛生蛋白的使用作为治疗目标。然而,它仍然是必要继续这些研究,以实现更好地理解这种蛋白质在肿瘤发生中的作用,并确定这些特定的情况下,其治疗的使用可能会更有利。 在本文中,我们将简要描述丛生蛋白的结构和遗传学,其在肿瘤的发生和肿瘤进展和预后的实用意义。最后,我们将分析在不同类型的癌症中的作用。
关键词: 丛生蛋白,癌细胞凋亡,化疗,反义寡核苷酸,靶向治疗
Current Medicinal Chemistry
Title:The Role of Clusterin in Carcinogenesis and its Potential Utility as Therapeutic Target
Volume: 23 Issue: 38
Author(s): T. Tellez, M. Garcia-Aranda, M. Redondo
Affiliation:
关键词: 丛生蛋白,癌细胞凋亡,化疗,反义寡核苷酸,靶向治疗
摘要: Clusterin is a glycoprotein that has been implicated in many processes, including apoptosis, cell cycle regulation and DNA repair. Since clusterin expression has also been associated with tumorigenesis and the progression of various malignancies including prevalent tumors like prostate, colon, bladder and breast, this protein has been proposed as a good candidate for future treatments.
There have been numerous studies conducted in cell lines and xenograft models with successful results that, in general, justify the use of clusterin as a therapeutic target. However, it is still necessary to continue with these studies in order to achieve a better understanding of the role of this protein in carcinogenesis and to determine those specific situations in which its therapeutic use may be more favorable.
In this review, we will make a brief description of clusterin structure and genetics, its implication in tumorigenesis and cancer progression and its prognosis utility. Finally, we will analyze the effects of clusterin inhibition in different types of cancer.
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Cite this article as:
T. Tellez, M. Garcia-Aranda, M. Redondo , The Role of Clusterin in Carcinogenesis and its Potential Utility as Therapeutic Target, Current Medicinal Chemistry 2016; 23 (38) . https://dx.doi.org/10.2174/0929867323666161024150540
DOI https://dx.doi.org/10.2174/0929867323666161024150540 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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