非酒精性脂肪性肝炎发病机制的新的研究方面

Title:Novel Aspects in the Pathogenesis of Nonalcoholic Steatohepatitis

Volume: 16 Issue: 8

Author(s): A. Gentilini, A. Caligiuri, A. Provenzano, F. Marra

Affiliation:

关键词: 非酒精性脂肪性肝炎；非酒精性脂肪性肝病；纤维化

摘要: Nonalcoholic steatohepatitis (NASH) is a progressive form of nonalcoholic fatty liver disease, characterized by inflammation, hepatocyte injury and fibrogenesis. Overall mortality, and liver-related mortality, are both increased in NASH patients. Considering that nonalcoholic fatty liver disease is the most prevalent hepatic abnormality in the Western world, understanding the mechanisms leading to NASH and its progression to cirrhosis is critical for a better management of these patients. Moreover, a more detailed knowledge of this condition may be helpful to identify those subjects which are more susceptible to develop progressive liver disease. Emerging data indicate that NASH progression results from parallel events originating from the liver as well as from the adipose tissue, and the gastrointestinal tract. In this review we highlight some of the most recent findings reported on the pathogenesis of NASH and its fibrogenic progression to cirrhosis, in an effort to identify possible targets for treatment or biomarkers of disease progression.

Cite this article as:

A. Gentilini, A. Caligiuri, A. Provenzano, F. Marra , Novel Aspects in the Pathogenesis of Nonalcoholic Steatohepatitis, Current Molecular Medicine 2016; 16 (8) . https://dx.doi.org/10.2174/1566524016666161021163252