Synthesis and Antiproliferative Activities of Novel O-Benzyl Salicylamide Derivatives

Title:Synthesis and Antiproliferative Activities of Novel O-Benzyl Salicylamide Derivatives

Volume: 14 Issue: 6

Author(s): Jan Dusek, Ales Imramovsky, Karel Pauk, Radek Jorda, Eva Reznickova and Vladimir Krystof

Affiliation:

Keywords: Salicylamides, antiproliferative activity, cytotoxic activity, pharmacological activity, amines.

Abstract: Background: On the basis that various substituted salicylamides have shown interesting biological properties, we designed and synthesized new salicylamide derivatives with dipeptide moieties.

Methods: The synthesis was based on the gradual building of target molecules and provided optically pure compounds.

Conclusion: The obtained compounds were tested for their antiproliferative effect against three leukaemia cell lines in vitro and displayed GI50 values in the mid-micromolar range.

Cite this article as:

Dusek Jan, Imramovsky Ales, Pauk Karel, Jorda Radek, Reznickova Eva and Krystof Vladimir, Synthesis and Antiproliferative Activities of Novel O-Benzyl Salicylamide Derivatives, Letters in Drug Design & Discovery 2017; 14 (6) . https://dx.doi.org/10.2174/1570180813666161020113827

DOI https://dx.doi.org/10.2174/1570180813666161020113827	Print ISSN 1570-1808
Publisher Name Bentham Science Publisher	Online ISSN 1875-628X