Microwave Assisted Copper-catalyzed Synthesis of Substituted Benzamides Through Decarboxylative C-N Cross Coupling

Title:Microwave Assisted Copper-catalyzed Synthesis of Substituted Benzamides Through Decarboxylative C-N Cross Coupling

Volume: 4 Issue: 2

Author(s): Aniket P. Sarkate*, Dattatraya N. Pansare, Kshipra S. Karnik, Ishwari A. Kale, Sushilkumar S. Bahekar and Devanand B. Shinde

Affiliation:

• Department of Chemical Technology, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad, 431004 (MS),India

Keywords: Benzamides, copper, coupling, microwave, synthesis.

Abstract: Background: An efficient, microwave assisted, copper catalyzed synthetic protocol for substituted benzamides has been developed by using salts of carboxylic acids.

Methods: In the synthetic method, the targeted substituted benzamides were synthesized with the help of microwave by reacting salts of carboxylic acid and benzamides in the presence of copper and dimethyl formamide.

Results: All substituted benzamides were obtained in good yield (93-99%) with the help of a microwave technique (12-15 min) in the less time as compared to the conventional method.

Conclusion: Microwave assisted technique will be a useful alternative protocol for the preparation of diverse range of substituted benzamides.

Cite this article as:

Sarkate P. Aniket*, Pansare N. Dattatraya, Karnik S. Kshipra, Kale A. Ishwari, Bahekar S. Sushilkumar and Shinde B. Devanand, Microwave Assisted Copper-catalyzed Synthesis of Substituted Benzamides Through Decarboxylative C-N Cross Coupling, Current Microwave Chemistry 2017; 4 (2) . https://dx.doi.org/10.2174/2213335603666161017120230

DOI https://dx.doi.org/10.2174/2213335603666161017120230	Print ISSN 2213-3356
Publisher Name Bentham Science Publisher	Online ISSN 2213-3364