摘要
在临床和实验计划中,为了保护细胞和组织抵御有害的环境,并促进代谢从入侵中恢复过来,我们做出了大量的努力。最近大家的注意力都集中在糖的自然形态保护作用,1,6 -二磷酸果糖(F16bP)。 F16bP是一种高能糖酵解中间体,其保护了不同类型的细胞和组织(包括脑、肾、肠、肝、心)以及抵御了各种有害的条件。例如,有证据表明其抵御了由于缺血缺氧造成的神经损害。此外,F16bP的神经保护作用已经被由化学试剂或者冷藏的病变所记录了。败血症的死亡率下降了,甚至可以预防实验性骨质疏松中的骨损伤。有趣的是,在不同的靶标和动物模型的保护里,暗示了由F16bP诱导的机制是复杂的并涉及了许多不同的通路。 本篇综述,我们将讨论关于F16bP内细胞的分子作用模型的最新最近的理论,这些措施包括将其作为能量底物,ATP可用性的改善机制,并保存细胞器膜的稳定性和功能。此外,我们将提出新的证据,关于F16bp通过限制自由基的产生来降低氧化应激的能力和改善抗氧化功能的系统,包括一氧化氮在诱导f16bp保护机制中的作用。最后,我们将回顾其机制以解释抗炎,免疫调节和神经保护特性。
关键词: 1,6 -二磷酸果糖,钙螯合,神经保护作用,抗惊厥,免疫保护,氧化应激,抗氧化剂,骨质疏松。
Current Medicinal Chemistry
Title:Fructose 1,6-Bisphosphate: A Summary of Its Cytoprotective Mechanism
Volume: 23 Issue: 39
Author(s): Norma Alva, Ronald Alva, Teresa Carbonell
Affiliation:
关键词: 1,6 -二磷酸果糖,钙螯合,神经保护作用,抗惊厥,免疫保护,氧化应激,抗氧化剂,骨质疏松。
摘要: In clinical and experimental settings, a great deal of effort is being made to protect cells and tissues against harmful conditions and to facilitate metabolic recovery following these insults. Much of the recent attention has focused on the protective role of a natural form of sugar, fructose 1,6-bisphosphate (F16bP).
F16bP is a high-energy glycolytic intermediate that has been shown to exert a protective action in different cell types and tissues (including the brain, kidney, intestine, liver and heart) against various harmful conditions. For example, there is much evidence that it prevents neuronal damage due to hypoxia and ischemia. Furthermore, the cytoprotective effects of F16bP have been documented in lesions caused by chemicals or cold storage, in a decrease in mortality during sepsis shock and even in the prevention of bone loss in experimental osteoporosis. Intriguingly, protection in such a variety of targets and animal models suggests that the mechanisms induced by F16bP are complex and involve different pathways.
In this review we will discuss the most recent theories concerning the molecular model of action of F16bP inside cells. These include its incorporation as an energy substrate, the mechanism for the improvement of ATP availability, and for preservation of organelle membrane stability and functionality. In addition we will present new evidences regarding the capacity of F16bP to decrease oxidative stress by limiting free radical production and improving antioxidant systems, including the role of nitric oxide in the protective mechanism induced by F16bP. Finally we will review the proposed mechanisms for explaining its anti-inflammatory, immunomodulatory and neuroprotective properties.
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Cite this article as:
Norma Alva, Ronald Alva, Teresa Carbonell , Fructose 1,6-Bisphosphate: A Summary of Its Cytoprotective Mechanism, Current Medicinal Chemistry 2016; 23 (39) . https://dx.doi.org/10.2174/0929867323666161014144250
DOI https://dx.doi.org/10.2174/0929867323666161014144250 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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