Gastrointestinal Motility and Acute Toxicity of Pistagremic Acid Isolated from the Galls of Pistacia integerrima

Title:Gastrointestinal Motility and Acute Toxicity of Pistagremic Acid Isolated from the Galls of Pistacia integerrima

Volume: 13 Issue: 3

Author(s): Abdur Rauf*, Tareq Abu-Izneid, Aneela Maalik, Saud Bawazeer, Ajmal Khan, Taibi Ben Hadda, Haroon Khan, Mohamed Fawzy Ramadan, Imran Khan, Mohammad S. Mubarak, Ghias Uddin, Alia Bahadar and Umar Farooq

Affiliation:

• Department of Chemistry, University of Swabi, Ambar-23561, Khyber Pakhtunkhwa,Pakistan

Keywords: Pistacia integerima, pistagremic acid, acute toxicity, GIT motility test, dose-dependent reduction, charcoal meal.

Abstract: Background: Pistacia integerrima has many medicinal uses in therapeutic as well as folk medicine. P. integerrima has been used for the treatment of different ailments such as blood purifier, anti-inflammatory, and as remedy for gastrointestinal disorders such as vomiting and diarrhea, expectorant, cough, asthma and fever.

Objective: The main objective of this research work was to evaluate the effect of pistagremic acid (PA) isolated from the galls of Pistacia integerima in acute toxicity and gastrointestinal (GIT) motility tests.

Methods: Compound 1 namely pistagremic acid (PA) (at 10, 50, 100 mg/kg i.p) were assessed for their in-vivo gastrointestinal motility test using charcoal screening model.

Results: Results revealed that pretreatment of PA exhibited substantial safety in acute toxicity test up to the dose of 500 mg/kg p.o. However, when studied in charcoal meal GI transit test, PA caused significant (p < 0.05) attenuation of GIT motility and an increase in intestinal transit time, comparable to atropine (a muscarinic receptor blocking agent).

Conclusion: In conclusion, PA displayed a strong dose-dependent reduction in GIT motility with considerable safety.

Cite this article as:

Rauf Abdur*, Abu-Izneid Tareq, Maalik Aneela, Bawazeer Saud, Khan Ajmal, Hadda Ben Taibi, Khan Haroon, Ramadan Fawzy Mohamed, Khan Imran, Mubarak S. Mohammad, Uddin Ghias, Bahadar Alia and Farooq Umar, Gastrointestinal Motility and Acute Toxicity of Pistagremic Acid Isolated from the Galls of Pistacia integerrima, Medicinal Chemistry 2017; 13 (3) . https://dx.doi.org/10.2174/1573406412666161007145247

DOI https://dx.doi.org/10.2174/1573406412666161007145247	Print ISSN 1573-4064
Publisher Name Bentham Science Publisher	Online ISSN 1875-6638