摘要
咖啡饮料,在世界各地通过多种方法被制备,正日益成为我们生活的一部分。尽管近几十年被当做一种不健康的饮料,但是咖啡在医学期刊中越来越与减少多种疾病的风险相联系。如果这种饮料在现代社会能够给我们带来快乐,同时调节情绪降低多种疾病风险包括第二类糖尿病呢?基于最近的流行病调查数据,长期饮用咖啡的在健康的个体中有着更低的患第二类糖尿病率,这其中可能有复杂的与干扰葡萄糖代谢、抗氧化活性、抗炎标记物相关的机制。几种咖啡的成分可能潜在地影响了上文描述的机制,同时这种因素使他们的存在高度变化,其中与几种有趣的因素相关的成分如绿原酸、碱和b-卡琳。由于咖啡中存在的大量化合物,我们从他的成分中探索潜在的协同作用。更有甚者,大量的咖啡消耗显示出不同的健康影响基于长期消耗咖啡中,并且不是所有的咖啡饮料都相同。然而,尽管在上个十年开展了大量的研究,在咖啡预防降低第二类糖尿病的物质和机制的研究依然有待深入开展,不久将会将咖啡应用于此。
关键词: 咖啡,绿原酸,内脂,葫芦巴碱,b-卡琳,葡萄糖平衡,胰岛素耐受性,脂联素。
Current Medicinal Chemistry
Title:Coffee: A Dietary Intervention on Type 2 Diabetes?
Volume: 24 Issue: 4
关键词: 咖啡,绿原酸,内脂,葫芦巴碱,b-卡琳,葡萄糖平衡,胰岛素耐受性,脂联素。
摘要: Coffee beverages, prepared in a multitude of ways around the world, are increasingly part of our daily lives. Although considered an unhealthy beverage for decades, coffee is increasingly the headline of medical journals in association with a reduced risk for several diseases. What if this beverage could give us pleasure, while modulating mood and lowering the risk for several diseases of the modern society, including type 2 diabetes (T2D)? Based on the most recent epidemiological and research data, long-term consumption of coffee beverages is associated with a lower risk of developing T2D in healthy individuals, probably involving multiple mechanisms, with interventions on glucose homeostasis, antioxidant activity, and inflammatory biomarkers. Several coffee constituents potentially responsible for these effects are described, as well as the factors that make their presence highly variable, with interesting effects associated with chlorogenic acids, trigonelline and norharman. Due to the high number of compounds contained in coffee, we explore the potential synergic effect within the coffee matrix. Moreover, acute coffee consumption shows different health effects from those achieved on a long-term daily consumption, and not all coffee beverages are similar. Still, despite the huge amount or work developed in the last decade, the substances and mechanisms behind these protective effects on T2D are still to be fully elucidated, being therefore soon for dietary interventions based on coffee.
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Cite this article as:
Coffee: A Dietary Intervention on Type 2 Diabetes?, Current Medicinal Chemistry 2017; 24 (4) . https://dx.doi.org/10.2174/0929867323666161003123717
DOI https://dx.doi.org/10.2174/0929867323666161003123717 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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