摘要
背景:糖尿病视网膜病变是糖尿病的严重并发症之一,也是全球视力下降和失明的主要原因。现已认识到神经变性是导致视网膜损伤的起因,导致糖尿病视网膜病变中的微血管损伤。糖尿病诱导的氧化应激被认为是损害糖尿病视网膜神经元的关键因素。出现了各种有效减轻抗氧化剂氧化应激增加的治疗方法。一种方法是利用已经发现的具有强大抗氧化活性的膳食类黄酮。一些天然存在的黄酮通过增加糖尿病动物模型中的胰岛素敏感性和降低血浆葡萄糖水平而具有抗糖尿病作用。 目的:考虑到开发新型抗氧化剂的重要性及其应用于糖尿病及其并发症治疗的相关性,在本文中,我们讨论并突出了糖尿病视网膜中类黄酮的各种神经保护机制。 结果:向糖尿病患者补充黄酮类化合物可能会降低氧化应激,从而改善糖尿病视网膜的凋亡和神经营养因子的水平。 结论:该方法将阐明预防和治疗视力下降和失明的主要原因的糖尿病视网膜病变的新策略。
关键词: 类黄酮,糖尿病性视网膜病变,神经保护,视网膜,神经变性,氧化应激。
图形摘要
Current Drug Targets
Title:Protective Effects of Dietary Flavonoids in Diabetic Induced Retinal Neurodegeneration
Volume: 18 Issue: 13
关键词: 类黄酮,糖尿病性视网膜病变,神经保护,视网膜,神经变性,氧化应激。
摘要: Background: Diabetic retinopathy is one of the serious complications of diabetes and the leading cause of decreased vision and blindness worldwide. Neurodegeneration has been recognized as initiating factor in causing the retinal damage, which leads to micro-vascular damage in diabetic retinopathy. Diabetes-induced oxidative stress is believed to be the key factor that damages neurons in the diabetic retina. Various therapeutic approaches for effective attenuation of increased oxidative stress by antioxidants have emerged. One such approach is to utilize dietary flavonoids, which have been found to possess powerful antioxidant activity. Some of the naturally occurring flavones possess anti-diabetic effects by enhancing insulin sensitivity and reducing plasma glucose levels in diabetic animal models.
Objective: Considering the importance of developing new antioxidant compounds and the relevance of their applications in the treatment of diabetes and its complications, in this review article, we discuss and highlight various neuroprotective mechanisms of flavonoids in the diabetic retina. Results: Dietary supplementation of flavonoids to diabetics may reduce oxidative stress, which in turn might ameliorate apoptosis and the levels of neurotrophic factors in the diabetic retina. Conclusion: This approach will elucidate a novel strategy for preventing and treating diabetic retinoneuropathy the leading cause of low vision and blindness.Export Options
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Cite this article as:
Protective Effects of Dietary Flavonoids in Diabetic Induced Retinal Neurodegeneration, Current Drug Targets 2017; 18 (13) . https://dx.doi.org/10.2174/1389450117666161003121304
DOI https://dx.doi.org/10.2174/1389450117666161003121304 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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