摘要
阿尔兹海默病(AD)是当前难以得到有效治疗的一种迫在眉睫影响公众健康的疾病。无创脑刺激(NBS),特别是经颅磁刺激(TMS)和经颅直流电刺激(tDCS)为越来越多的神经和精神病症状的药理学干预提供了有希望的替代方法。本文目的是为了对NBS在AD和其他痴呆性疾病治疗性数据进行综述。尽管NBS有治疗潜力,但是应用于AD中仍存在一些局限性地治疗框架和缺乏治疗。已发表的一些临床试验没有报道相互作用的关键参数,因此也限制了此研究评估其有效性和安全性的效用价值。本文包括为进一步研究所给出的建议,旨在推进将NBS作为AD引起的症状和残疾的治疗发展并能够实现结果交叉试验的比较。最后,需要进行适当的、可控的和多位点随机临床试验来评估NBS在AD中的治疗潜力。
关键词: 阿尔兹海默症,经颅磁刺激(TMS),经颅直流电刺激,痴呆,无创脑刺激
Current Alzheimer Research
Title:Therapeutic Noninvasive Brain Stimulation in Alzheimer’s Disease
Volume: 14 Issue: 4
关键词: 阿尔兹海默症,经颅磁刺激(TMS),经颅直流电刺激,痴呆,无创脑刺激
摘要: Alzheimer’s disease (AD) is a looming public health crisis that currently lacks an effective treatment. Noninvasive Brain Stimulation (NBS), particularly transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS), offers a promising alternative approach to pharmacological interventions for an increasing number of neurological and psychiatric conditions. The aim of this review is summarize data from therapeutic trials of NBS in AD and other dementing illnesses.
Despite the potential of NBS, there is limited theoretical framework and a lack of guidelines for its applications to AD. Several published clinical trials failed to report key parameters of the interventions thus limiting the utility of the study to assess efficacy and safety. Our review concludes with some suggestions for future studies aimed to advance research into NBS as a potential treatment for the symptoms and disabilities caused by AD and to enable comparison of results across trials. Ultimately, appropriately powered, and controlled, multi-site randomized clinical trials will be needed to evaluate the therapeutic potential of NBS in AD.Export Options
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Cite this article as:
Therapeutic Noninvasive Brain Stimulation in Alzheimer’s Disease, Current Alzheimer Research 2017; 14 (4) . https://dx.doi.org/10.2174/1567205013666160930113907
DOI https://dx.doi.org/10.2174/1567205013666160930113907 |
Print ISSN 1567-2050 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5828 |
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