摘要
阿尔兹海默症预防领域一直是基础科学、临床和翻译研究的热点。自从2011AD诊断指南的发布,在过去的三年,大规模的合作开始了新的临床试验,期望有一天能够预防AD。本文将阐明这些试验所依据的历史和科学背景,并讨论这些试验在以后所可能面临的问题,分析主要的预防措施包括生活方式、多领域、药物和补充剂干预。回顾以疾病缓解干预为代表的二级预防,如抗淀粉样蛋白治疗和吡格列酮治疗。最后,还将提出关于AD预防试验的未来方向的假设。
关键词: 阿尔兹海默症、神经心理学、病理生理学、焦虑、高血压
Current Alzheimer Research
Title:Primary and Secondary Prevention Trials in Alzheimer Disease: Looking Back, Moving Forward
Volume: 14 Issue: 4
关键词: 阿尔兹海默症、神经心理学、病理生理学、焦虑、高血压
摘要: The field of Alzheimer disease (AD) prevention has been a culmination of basic science, clinical, and translational research. In the past three years since the new 2011 AD diagnostic guidelines, large-scale collaborative efforts have embarked on new clinical trials with the hope of someday preventing AD. This review will shed light on the historical and scientific contexts in which these trials were based on, as well as discuss potential challenges these trials may face in the coming years. Primary preventive measures, such as lifestyle, multidomain, medication, and supplemental interventions, will be analyzed. Secondary prevention as represented by disease-modifying interventions, such as antiamyloid therapy and pioglitazone, will also be reviewed. Finally, hypotheses on future directions for AD prevention trials will be proposed.
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Primary and Secondary Prevention Trials in Alzheimer Disease: Looking Back, Moving Forward, Current Alzheimer Research 2017; 14 (4) . https://dx.doi.org/10.2174/1567205013666160930112125
DOI https://dx.doi.org/10.2174/1567205013666160930112125 |
Print ISSN 1567-2050 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5828 |
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