Tip60: Main Functions and Its Inhibitors

Title:Tip60: Main Functions and Its Inhibitors

Volume: 17 Issue: 8

Author(s): Xiaoli Zhang, Jiyong Wu and Yepeng Luan*

Affiliation:

• Department of Medicinal Chemistry, School of Pharmacy, Qingdao University, Qingdao, Shandong Province,China

Keywords: Cancer, ε-amino, HATs, HDACs, histone acetyltransferase, inhibitor, Tip60.

Abstract: Background: Tip60, the founding member of MYST histone acetyltransferase family, was originally identified as a cellular acetyltransferase protein that interacts with HIV-1 Tat. Tip60 plays roles in many processes such as cellular signaling transmission, DNA damage repair, cell cycle and checkpoint control and apoptosis by acetylating its histone or non-histone substrates.

Cite this article as:

Zhang Xiaoli, Wu Jiyong and Luan Yepeng*, Tip60: Main Functions and Its Inhibitors, Mini-Reviews in Medicinal Chemistry 2017; 17 (8) . https://dx.doi.org/10.2174/1389557516666160923125031