Functions of Type II Thioesterases in Bacterial Polyketide Biosynthesis

Title:Functions of Type II Thioesterases in Bacterial Polyketide Biosynthesis

Volume: 23 Issue: 11

Author(s): Hong-Dou Luo, Mei-Ying Jin, Hui Wu and Hui Jiang

Affiliation:

Keywords: Thioesterase, polyketide, synthase, biosynthesis, function.

Abstract: Many polyketides show biological activities and have thus been applied in clinics, as food additives, and in agriculture. Type II thioesterases (TEIIs) play an important role in polyketide biosynthesis. Most TEIIs belong to α/β-hydrolase family and usually contain a catalytic triad Ser-His-Asp. In polyketide biosynthesis, TEIIs can play an editing role by removal of aberrant non-extendable acyl units in elongation steps, a starter unit selection role by removal of unfavored starter acyl units in initiation steps, and a releasing role by removal of final product in termination steps. Complementation of TEIIs has been observed and applied.

Cite this article as:

Luo Hong-Dou, Jin Mei-Ying, Wu Hui and Jiang Hui, Functions of Type II Thioesterases in Bacterial Polyketide Biosynthesis, Protein & Peptide Letters 2016; 23 (11) . https://dx.doi.org/10.2174/0929866523666160920095131

DOI https://dx.doi.org/10.2174/0929866523666160920095131	Print ISSN 0929-8665
Publisher Name Bentham Science Publisher	Online ISSN 1875-5305