摘要
紫杉醇科是一家由紫杉萜(红豆杉属)生产的,广泛使用在化疗。这个科包括紫杉醇、多烯紫杉醇和最近添加的卡巴他赛,所有这一切都被证明是有前景的抗癌药物。由于过度采伐的危险威胁着紫杉树,以及许多挑战以紫杉类为基础的化疗,所以面临着新的配方,类似物和输送系统的要求。在这里,我们对同期综述论文进行了书目数据库PubMed的结构化搜索,基于紫杉烷药物输送方法的信息依靠关键词和出版日期和组织。论文检索的期刊具有显著的影响和可比范围。共有126篇论文进行了审查,其中81个发布到紫杉烷制剂和纳米颗粒的相关工作,22集中在来自三紫杉醇类似物。虽然最近的文章探讨紫杉醇制剂的有效性,但是这些制剂大多仍在临床前的水平。然而,许多的紫杉醇类似物目前正在为侵袭性癌二线治疗的临床试验或使用与其他化疗药物联合。调查结果证实了开发新的给药策略和紫杉醇类似物的重要性,提高疗效,目前常用的化疗药物。这项发现是由FDA批准紫杉醇给药,消除有毒溶剂的需要制定进一步的支持,与多西他类似物拟卡巴他赛,它能减少了外排泵的亲和力。
关键词: 抗肿瘤,紫杉,紫杉醇
Current Medicinal Chemistry
Title:Overview of the Formulations and Analogs in the Taxanes' Story
Volume: 23 Issue: 40
Author(s): Farah Yassine, Elia Salibi, Hala Gali-Muhtasib
Affiliation:
关键词: 抗肿瘤,紫杉,紫杉醇
摘要: Taxanes are a family of diterpenes produced by the yews (Taxus genus) that are extensively used in chemotherapy. The family encompasses paclitaxel, docetaxel and the recently added cabazitaxel, all of which were proven to be promising anti-cancer drugs. Due to the over harvesting danger threatening the yew trees as well as the many challenges faced by taxane-based chemotherapy, new formulations, analogs and delivery systems are required. Here, we undertook a structured search of the bibliographical database PubMed for peerreviewed research papers relying on key words and date of publication and organized the information based on the method of taxane drug delivery. Papers retrieved were from journals with significant impact and comparable scope. A total of 126 papers were reviewed, 81 of which published work related to the taxane formulations and nanoparticles, and 22 focused on the analogs derived from the three taxanes. Although recent articles investigate the effectiveness of taxane formulations, most of these formulations are still at the pre-clinical level. However, many of the taxane analogs are currently in clinical trials as second line treatment of aggressive cancers or are used in combination with other chemotherapeutic drugs. The findings corroborate the importance of developing new drug delivery strategies and taxane analogs to improve the efficacy of currently used chemotherapeutic drugs. This finding is further supported by the FDA-approved formulation of paclitaxel that eliminates the need for toxic solvents for drug administration, and the docetaxel analog cabazitaxel which has decreased affinity for efflux pumps.
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Cite this article as:
Farah Yassine, Elia Salibi, Hala Gali-Muhtasib , Overview of the Formulations and Analogs in the Taxanes' Story, Current Medicinal Chemistry 2016; 23 (40) . https://dx.doi.org/10.2174/0929867323666160907124013
DOI https://dx.doi.org/10.2174/0929867323666160907124013 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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