New Page to Access Pyrazines and their Ring Fused Analogues: Synthesis from N-Propargylamines

Title:New Page to Access Pyrazines and their Ring Fused Analogues: Synthesis from N-Propargylamines

Volume: 14 Issue: 4

Author(s): Esmail Vessally*, Akram Hosseinian, Ladan Edjlali, Ahmadreza Bekhradnia*Mehdi D. Esrafili

Affiliation:

• Department of Chemistry, Payame Noor University, Tehran, Iran; Pharmaceutical Sciences Research Center, Department of Medicinal Chemistry, Mazandaran University of Medical Sciences, Sari,Iran

• Pharmaceutical Sciences Research Center, Department of Medicinal Chemistry, Mazandaran University of Medical Sciences, Sari,Iran

Keywords: Pyrazines, ring fused pyrazines, N-propargylamines, 6-exo-dig cyclization, 1, 3-dipolar cycloaddition.

Abstract: The development of efficient routes to pyrazines and their ring fused analogues is an attractive area of research since these compounds are now widely recognized as important N-heterocycles for their potential use in medicinal and agricultural scientific fields. In this review, we describe the most representative and interesting methods for the synthesis of pyrazines from N-propargylamines. Mechanistic aspects of the reactions are considered and discussed in detail.

Cite this article as:

Vessally Esmail*, Hosseinian Akram, Edjlali Ladan, Bekhradnia Ahmadreza*, Esrafili D. Mehdi, New Page to Access Pyrazines and their Ring Fused Analogues: Synthesis from N-Propargylamines, Current Organic Synthesis 2017; 14 (4) . https://dx.doi.org/10.2174/1570179413666160818144816