摘要
在过去的十年中,耐药侵袭性真菌病变得更普遍了,人们正在寻找新的抗真菌药物和靶向给药的方法。其中最大的障碍之一是真菌与人体的基本代谢途径相同。在寻找可能选择的疗法时,我们可以尝试一下它们代谢之间一个的显著差别,锌的摄入(一个真菌存活和毒性的营养关键)。 这个研究总结了最近生物无机化学中真菌锌摄入的进展。在特别关注病原体和其宿主之间恒定的锌的激战这一概念后,我们发现宿主试图保留基本的Zn(II),病原体则产生高亲和力锌结合分子来对抗,此后我们详细讨论了锌摄入的调节,它的各种形式的膜转运,储存和细胞内锌稳态平衡的维系。
关键词: 真菌细胞内锌稳态,锌的跨膜转运,锌储存,zincophores
Current Medicinal Chemistry
Title:Fungal Zinc Homeostasis – A Tug of War Between the Pathogen and Host
Volume: 23 Issue: 32
Author(s): Paulina K. Walencik, Joanna Watly, Magdalena Rowinska-Zyrek
Affiliation:
关键词: 真菌细胞内锌稳态,锌的跨膜转运,锌储存,zincophores
摘要: In the last decade, drug resistant invasive mycoses have become significantly more common and new antifungal drugs and ways to specifically deliver them to the fungal cell are being looked for. One of the biggest obstacles in finding such comes from the fact that fungi share essential metabolic pathways with humans. One significant difference in the metabolism of those two cells that can be challenged when looking for possible selective therapeutics is the uptake of zinc, a nutrient crucial for the fungal survival and virulence.
This work summarizes the recent advances in the biological inorganic chemistry of zinc metabolism in fungi. The regulation of zinc uptake, various types of its transmembrane transport, storage and the maintenance of intracellular zinc homeostasis is discussed in detail, with a special focus on the concept of a constant ‘tug of war’ over zinc between the fungus and its host, with the host trying to withhold essential Zn(II), and the fungus counteracting by producing high-affinity zinc binding molecules.
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Cite this article as:
Paulina K. Walencik, Joanna Watly, Magdalena Rowinska-Zyrek , Fungal Zinc Homeostasis – A Tug of War Between the Pathogen and Host, Current Medicinal Chemistry 2016; 23 (32) . https://dx.doi.org/10.2174/0929867323666160817163834
DOI https://dx.doi.org/10.2174/0929867323666160817163834 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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