摘要
先天免疫系统在微生物感染和组织再生过程中产生的炎症反应,可以起调节作用。甘露糖结合凝集素(MBL)是先天免疫系统启动的一个激活补体凝集素途径的主要组成部分之一。补体系统的激活也与许多人类疾病有关。因此,我们总结了寄血清甘露糖结合凝集素早期检测的预后价值(MBL)及其含量的测定。变异MBL2基因和MBL基因多态性相关的单核苷酸替换导致了感染风险增加。根据现有的证据,MBL在人类的作用是双方面的;有时它的存在与病理条件恶化有关,而在其他情况下,它是机体防御系统的重要组成部分。血清浓度测定作为诊断标志物是妥善解决后血浆纯化或重组MBL的重要指标,这可能是一个潜在的治疗人类疾病的替代品。我们总结了在各种疾病的早期病理生理的关键作用, 发现MBL是一个新的治疗靶点。
关键词: 甘露糖结合凝集素;先天免疫系统;多态性;补体激活;生物标志物;治疗目标。
Current Medicinal Chemistry
Title:Mannose Binding Lectin: A Potential Biomarker for Many Human Diseases
Volume: 23 Issue: 33
Author(s): Senjam Sunil Singh, Randy Chi Fai Cheung, Jack Ho Wong and Tzi Bun Ng
Affiliation:
关键词: 甘露糖结合凝集素;先天免疫系统;多态性;补体激活;生物标志物;治疗目标。
摘要: The innate immune system plays a modulatory role in producing an inflammatory response during microbial infection and tissue regeneration. Mannose-binding lectin (MBL) is a predominant constituent of the innate immune system which initiates one of the complement activation, the lectin pathway. The activation of the complement system is also associated with many human diseases. We, therefore, try to summarize herewith the prognostic value of early detection of serum mannose-binding lectin (MBL) and measurement of its levels. The variant alleles and single nucleotide substitutions in MBL2 gene associated with MBL polymorphism are responsible for an increased risk of infection. Based on the currently available evidence, the role of MBL in humans is a double facet; sometimes its presence is associated with deterioration of the pathological condition while in other cases it is an important part of the body defense system. The importance of the determination of serum MBL as a diagnostic biomarker is duly addressed and then substitution of plasma-purified or recombinant MBL which can be a potential therapeutic for the treatment of human diseases is also highlighted. We have summarized in this article the pivotal roles of MBL in the early pathophysiology of various diseases and shown that MBL serves as a novel therapeutic target.
Export Options
About this article
Cite this article as:
Senjam Sunil Singh, Randy Chi Fai Cheung, Jack Ho Wong and Tzi Bun Ng , Mannose Binding Lectin: A Potential Biomarker for Many Human Diseases, Current Medicinal Chemistry 2016; 23 (33) . https://dx.doi.org/10.2174/0929867323666160817162208
DOI https://dx.doi.org/10.2174/0929867323666160817162208 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Antioxidant Activity of Galantamine and Some of its Derivatives
Current Medicinal Chemistry Stem Cells Derived from Human Exfoliated Deciduous Teeth (SHED) in Neuronal Disorders: A Review
Current Stem Cell Research & Therapy Stem Cells and Cardiac Disease: Where are We Going?
Current Stem Cell Research & Therapy ADAM10 as a Therapeutic Target for Cancer and Inflammation
Current Pharmaceutical Design Anesthetic Neuroprotection: Antecedents and An Appraisal of Preclinical and Clinical Data Quality
Current Pharmaceutical Design From Preclinical to Clinical Trials: An Update on Potential Therapies for Huntington’s Disease
Current Psychopharmacology Early, Intensive and Long-term Statin Therapy in Acute Coronary Syndrome: Focus on Anti-inflammatory Mechanisms
Vascular Disease Prevention (Discontinued) Modulation of Cell Death in Age-Related Diseases
Current Pharmaceutical Design Testosterone and Cardioprotection Against Myocardial Ischemia
Cardiovascular & Hematological Disorders-Drug Targets Editorial (Thematic Issue: Renal Endothelial Dysfunction: Evolving Concepts And Perspectives)
Cardiovascular & Hematological Disorders-Drug Targets Editorial: Still Water Runs Deep
Current Molecular Medicine Early Ischemic Blood Brain Barrier Damage: A Potential Indicator for Hemorrhagic Transformation Following Tissue Plasminogen Activator (tPA) Thrombolysis?
Current Neurovascular Research Mitochondrial Therapeutics for Cardioprotection
Current Pharmaceutical Design Curcumin Targets p53-Fibrinolytic System in TGF-β1 Mediated Alveolar Epithelial Mesenchymal Transition in Alveolar Epithelial Cells
Endocrine, Metabolic & Immune Disorders - Drug Targets Editorial [Hot Topic Management of Perioperative Systemic Inflammation During Cardiopulmonary Bypass: We Need a Multimodal Approach (Guest Editor: David Faraoni)]
Recent Patents on Cardiovascular Drug Discovery Human Milk has Anti-Oxidant Properties to Protect Premature Infants
Current Pediatric Reviews Anti-inflammatory and Antioxidant Agents from Salvia Genus (Lamiaceae): An Assessment of the Current State of Knowledge
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry New Therapies to Modulate Post-Infarction Inflammatory Alterations in the Myocardium: State of the Art and Forthcoming Applications
Current Radiopharmaceuticals Interactive Effect of Cigarette Smoking and Gene Variants for Predisposing to Cardiovascular Disease
Current Pharmaceutical Design Triiodothyronine (T3) Effects on Cardiovascular System in Patients with Heart Failure
Recent Patents on Cardiovascular Drug Discovery