摘要
多年来,天然产物在体外,体内研究和临床试验中作为抗糖尿病药物已经取得了成功。由于与传统疗法相比,天然产物衍生药物更经济实惠且副作用更少,因此药物研究越来越倾向于从天然产物中发现新的抗糖尿病药物,这些药物靶向与2型糖尿病(T2DM)病理生理学相关的途径或组分。 。然而,药物发现过程非常漫长且成本高昂且存在重大挑战。因此,目前正在开发用于药物发现的临床前研究阶段的各种技术,其目的是通过天然产物的较少时间和努力进行药物开发。在这篇综述中,我们从体内,体外和临床研究中提供了天然产品的最新信息,包括水果,蔬菜,香料,坚果,饮料和蘑菇,以及潜在的抗糖尿病活性。还记录了天然产物和抗糖尿病药物以及来自天然产物的潜在抗糖尿病活性化合物之间的协同相互作用,以分别为组合治疗和新药物发现铺平道路。此外,还讨论了药物发现过程的简要概念以及天然产物药物开发过程中出现的挑战以及克服这些挑战的方法,以创建更方便的未来药物发现过程。
关键词: 2型糖尿病,天然产物,体内,体外,抗糖尿病药物,协同相互作用,药物开发。
Current Medicinal Chemistry
Title:Updates on Managing Type 2 Diabetes Mellitus with Natural Products: Towards Antidiabetic Drug Development
Volume: 25 Issue: 39
关键词: 2型糖尿病,天然产物,体内,体外,抗糖尿病药物,协同相互作用,药物开发。
摘要: Over the years, natural products have shown success as antidiabetics in in vitro, in vivo studies and clinical trials. Because natural product-derived drugs are more affordable and effective with fewer side-effects compared to conventional therapies, pharmaceutical research is increasingly leaning towards the discovery of new antidiabetic drugs from natural products targeting pathways or components associated with type 2 diabetes mellitus (T2DM) pathophysiology. However, the drug discovery process is very lengthy and costly with significant challenges. Therefore, various techniques are currently being developed for the preclinical research phase of drug discovery with the aim of drug development with less time and efforts from natural products. In this review, we have provided an update on natural products including fruits, vegetables, spices, nuts, beverages and mushrooms with potential antidiabetic activities from in vivo, in vitro and clinical studies. Synergistic interactions between natural products and antidiabetic drugs, and potential antidiabetic active compounds from natural products are also documented to pave the way for combination treatment and new drug discovery, respectively. Additionally, a brief idea of the drug discovery process along with the challenges that arise during drug development from natural products and the methods to conquer those challenges are discussed to create a more convenient future drug discovery process.
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Cite this article as:
Updates on Managing Type 2 Diabetes Mellitus with Natural Products: Towards Antidiabetic Drug Development, Current Medicinal Chemistry 2018; 25 (39) . https://dx.doi.org/10.2174/0929867323666160813222436
DOI https://dx.doi.org/10.2174/0929867323666160813222436 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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