设计与构建用于药物释放的具磁性反应的纳米载体

Title:Design and Fabrication of Magnetically Responsive Nanocarriers for Drug Delivery

Volume: 24 Issue: 5

关键词: 磁性纳米粒，纳米簇，磁性药物释放，铁氧化物纳米晶体，SPION簇，磁性命中，磁性纳米载体，磁性辅助释放。

摘要: Magnetically-assisted delivery of therapeutic agents to the site of interest, which is referred to as magnetic drug targeting, has proven to be a promising strategy in a number of studies. One of the key advantages over other targeting strategies is the possibility to control remotely the distribution and accumulation of the nanocarriers after parenteral administration. However, preparation of effective and robust magnetically responsive nanocarriers based on superparamagnetic iron oxide nanocrystals (SPIONs) still represents a great scientific challenge, since spatial guidance of individual SPIONs is ineffective despite the presence of high magnetic field gradient. A strategy to overcome this issue is the clustering of SPIONs to achieve sufficient magnetic responsiveness. In this mini-review, we address current and future strategies for the design and fabrication of magnetically responsive nanocarriers based on SPIONs for magnetically-targeted drug delivery, including the underlying physical requirements, the possibility of drug loading, and the control of drug release at the targeted site.

Cite this article as:

Design and Fabrication of Magnetically Responsive Nanocarriers for Drug Delivery, Current Medicinal Chemistry 2017; 24 (5) . https://dx.doi.org/10.2174/0929867323666160813211736