体外模型中的恶性神经胶质瘤：类干细胞的应用

Title:Malignant Glioma In Vitro Models: On the Utilization of Stem-like Cells

Volume: 17 Issue: 3

关键词: 成胶质瘤细胞，体外模型，胶质瘤样干细胞，肿瘤分析，TCGA，细胞培养，肿瘤异质性

摘要: Recent publications on the molecular characterization of malignant glioma have had profound impact on the appreciation of tumoral heterogeneity within and between patients. Both these phenomena are implicated in the variability in clinical outcome between patients, as well as the inevitable recurrence of these tumors after conventional treatment. The advent of selective cell culture protocols for the propagation of patient-derived glioma stem-like cells (GSCs) provides researchers the ability to selectively study the cells that could be at the root of tumor proliferation and resistance to therapy. As these techniques are widely applied in contemporary studies and becoming the preferred in vitro model, molecular characterization of GSCs is considered pivotal for the identification and advancement of novel therapies for this devastating disease.

Cite this article as:

Malignant Glioma In Vitro Models: On the Utilization of Stem-like Cells, Current Cancer Drug Targets 2017; 17 (3) . https://dx.doi.org/10.2174/1568009616666160813191809