摘要
目的:为阐明免疫检查点抑制剂在GBM管理中的作用 方法:通过在PubMed数据库以及已在临床试验中注册的试验中检索英文文献来获得GBM中免疫检查点抑制剂的临床前和临床试验信息,gov和摘要最近发表在国际大会中。 结果:免疫检查点抑制剂可能在设计未来GBM管理中免疫治疗方法起到了关键的作用。 结论:免疫检查点抑制剂可能是GBM中一个具有潜力的治疗方案。
关键词: 免疫治疗,多形性成胶质瘤细胞,检查点,放疗,PD-1,CTLA-4,ipilimumab
图形摘要
Current Cancer Drug Targets
Title:New Approaches in Glioblastoma Multiforme: The Potential Role of Immune- check Point Inhibitors
Volume: 17 Issue: 3
关键词: 免疫治疗,多形性成胶质瘤细胞,检查点,放疗,PD-1,CTLA-4,ipilimumab
摘要: Background: Glioblastoma multiforme (GBM) is the most frequent brain tumor. Despite recent advances in treatment approaches the prognosis remains poor, with a median overall survival of 14.6 months. Immunotherapy is the subject of ongoing research and its benefit is becoming evident in other malignancies. Immune check-points such as cytotoxic T lymphocyte associated antigen 4 (CTLA-4), programmed cell death receptor (PD-1) and indoleamine 2,3-dioxygenase (IDO) reduce immune response.
Objective: To clarify the role of immune check point inhibitors in GBM management. Methods: Preclinical and clinical trials of immune check-point inhibitors in GBM were obtained by searching for English peer-reviewed articles on PubMed databases, trials registered on clincaltrials. gov and abstracts recently presented at international congresses. Results: Immune check point inhibitors may be of critical importance for the design of future immunotherapy approaches in GBM management. Conclusion: Immune check-point inhibitors should be considered a promising treatment option in GBM.Export Options
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Cite this article as:
New Approaches in Glioblastoma Multiforme: The Potential Role of Immune- check Point Inhibitors, Current Cancer Drug Targets 2017; 17 (3) . https://dx.doi.org/10.2174/1568009616666160813183738
DOI https://dx.doi.org/10.2174/1568009616666160813183738 |
Print ISSN 1568-0096 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5576 |
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